Valsartan manufacturers and suppliers

Valsartan suppliers

Properties

Melting point:: 116-117°C

Boiling point:: 684.9±65.0 °C(Predicted)

Density: 1.212±0.06 g/cm3(Predicted)

vapor pressure: 0-0Pa at 20-25℃

storage temp.: 2-8°C

solubility: DMSO: ≥20mg/mL

pka: 3.56±0.10(Predicted)

form: powder

color: white to tan

optical activity: [α]/D -55 to -70°, c = 1 in methanol

Water Solubility: 84.99mg/L(25 ºC)

Merck: 14,9916

BCS Class: 2

Stability:: Hygroscopic

InChIKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N

LogP: 1.2-2.8 at 25℃ and pH2.5-7

Surface tension: 59.6-68.1mN/m at 10-100mg/L and 20℃

Dissociation constant: 3.76-4.38 at 25℃

CAS DataBase Reference: 137862-53-4(CAS DataBase Reference)

EPA Substance Registry System: L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (137862-53-4)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H336-H361d

Precautionary statements: P201-P308+P313

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-37/39

WGK Germany: 3

RTECS: YV9455000

HS Code: 29339900

Hazardous Substances Data: 137862-53-4(Hazardous Substances Data)

Use

Valsartan selectively affects the AT1 receptor subtype and prevents AT1 from binding with AT1 receptors (its selective AT1 receptor antagonizing effect is about 20000 times greater than its effects on AT2 receptors), thus inhibiting vasoconstriction and aldosterone release, producing an antihypertensive effect, but it cannot inhibit the release of aldosterone caused by potassium ions (K+). Valsartan does not affect angiotensin-converting enzymes (ACE) or renin and its receptors, and it does not inhibit ion channels related to blood pressure regulation and sodium balance. Valsartan does not inhibit ACE and does not affect bodily bradykinin levels, thus causing less coughing side effects than ACE inhibitors. Valsartan does not affect heart rate when lowering blood pressure. Sudden ceasing in Valsartan use will not cause rebound hypertension or other side effects. Valsartan does not affect hypertension patients overall cholesterol, triglyceride, blood glucose, or uric acid levels.

You can find Valsartan suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.