Verapamil manufacturers and suppliers

Verapamil suppliers

Properties

Melting point:: 25°C

Boiling point:: 243-246 °C (1.3 Pa)

Density: 1.1267 (rough estimate)

refractive index: 1.5448

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: DMSO: 100 mg/mL (219.97 mM)

pka: 8.6(at 25℃)

form: Thick Oil

color: Colourless

InChI: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3

InChIKey: SGTNSNPWRIOYBX-UHFFFAOYSA-N

SMILES: C(C1C=CC(OC)=C(OC)C=1)(C#N)(C(C)C)CCCN(C)CCC1C=CC(OC)=C(OC)C=1

CAS DataBase Reference: 52-53-9(CAS DataBase Reference)

NIST Chemistry Reference: Verapamil(52-53-9)

EPA Substance Registry System: Verapamil (52-53-9)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazardous Substances Data: 52-53-9(Hazardous Substances Data)

Toxicity: LD50 oral in rat: 163mg/kg

Use

Verapamil, 5-[. Hemodynamically, verapamil causesa change in the preload, afterload, contractility, heart rate,and coronary blood flow. The drug reduces systemic vascularresistance and mean blood pressure, with minor effectson cardiac output.Verapamil is a synthetic compound possessing slightstructural similarity to papaverine. It can be separated intoits optically active isomers, of which the levorotatory enantiomeris the most potent. It is absorbed rapidly after oraladministration. The drug is metabolized quickly and, as aresult, has low bioavailability. The liver is the main siteof first-pass metabolism, forming several products. Thepreferential metabolic step involves N-dealkylation, followedby O-demethylation, and subsequent conjugation ofthe product before elimination. The metabolites have no significantbiological activity. Verapamil has an eliminationhalf-life of approximately 5 hours.

You can find Verapamil suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.