Ziprasidone manufacturers and suppliers

Ziprasidone suppliers

Properties

Melting point:: 213-215°C

Boiling point:: 554.8±50.0 °C(Predicted)

Density: 1.369±0.06 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

solubility: DMSO (Slightly), Methanol (Slightly)

pka: 13.34±0.20(Predicted)

form: Solid

color: Brown to Dark Brown

Merck: 14,10171

InChI: 1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)

InChIKey: MVWVFYHBGMAFLY-UHFFFAOYSA-N

SMILES: O=C1CC(C=C(C(Cl)=C2)CCN3CCN(CC3)C4=NSC5=C4C=CC=C5)=C2N1.[xHCl].[yH2O]

CAS DataBase Reference: 146939-27-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H317-H373

Precautionary statements: P260-P272-P280-P302+P352-P314-P333+P313

Hazard Codes: F,T

Risk Statements: 60-61-11-19-38

Safety Statements: 53-45

WGK Germany: WGK 3

RTECS: NM3241000

HS Code: 2934.20.8000

Storage Class: 11 - Combustible Solids

Hazard Classifications: Skin Sens. 1
STOT RE 2

Hazardous Substances Data: 146939-27-7(Hazardous Substances Data)

REACH Registrations: Active

Use

Ziprasidone, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, is available as the hydrochloride monohydrate for oral administration (Geodon) and as the mesylate trihydrate saltfor intramuscular (IM) injection. The compound is well absorbedwith peak plasma levels occurring at 6 to 8 hours afteroral administration. The oral absorption is enhanced approximatelytwofold in the presence of food. Ziprasidone isbound about 99% to plasma proteins, primarily to albuminand α1-acid glycoprotein. Ziprasidone is not displaced in thepresence of two highly protein bound drugs, warfarin andpropranolol. Ziprasidone is extensively metabolized withonly about 5 % of the drug excreted unchanged.23 In humans,two major pathways are responsible for the metabolism ofziprasidone: (a) oxidation by CYP3A4 (one third) and (b) reductionby aldehyde oxidase (two thirds).The combinedaction of these metabolic pathways leads to four majorcirculating metabolites: benzisothiazole piperazine sulfoxide(BITP-sulfoxide), benzisothiazole piperazine sulfone (BITPsulfone),ziprasidone sulfoxide, and S-methyldihydroziprasidone.

You can find Ziprasidone suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.