Zonisamide manufacturers and suppliers

Zonisamide suppliers

Properties

Melting point:: 275°C dec.

Boiling point:: 223°C (rough estimate)

Density: 1.4306 (rough estimate)

refractive index: 1.5690 (estimate)

Flash point:: 9℃

storage temp.: Keep in dark place,Sealed in dry,2-8°C

solubility: H₂O: >5 mg/mL, soluble

pka: 10.2(at 25℃)

form: solid

color: off-white

Merck: 14,10192

Major Application: pharmaceutical (small molecule)

InChI: 1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)

InChIKey: UBQNRHZMVUUOMG-UHFFFAOYSA-N

SMILES: [S](=O)(=O)(N)Cc1n[o]c2c1cccc2

CAS DataBase Reference: 68291-97-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H361

Precautionary statements: P280-P301+P312+P330

Hazard Codes: Xn,T,F

Risk Statements: 22-39/23/24/25-23/24/25-11

Safety Statements: 7-16-36/37-45

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 3

RTECS: DE4930000

HS Code: 2935904000

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral
Repr. 2

Hazardous Substances Data: 68291-97-4(Hazardous Substances Data)

Toxicity: LD50 in mice, rats (mg/kg): 1892, 2001 orally; 1273, 2569 s.c.; 699, 733 i.p.; 604, 748 i.v. (Masuda, 1980)

Use

Zonisamide is a new generation of sulfonamide anticonvulsant that is primarily used as supplemental therapy in treatment of partial seizures in combination with other antiepileptic medications. Besides, it is approved to be applied as an adjunctive therapy in adults suffering from infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic, and generalized tonic clonic seizure. Recent studies have proved that zonisamide can acts as a migraine preventative medication and is effective in several cases of neuropathic pain. In an open-label trial, zonisamide shows positive effects on attenuating the symptoms of tardive dyskinesia. Zonisamide is a broad-spectrum antiepileptic effective in the treatment of refractory seizures. In cultured spinal cord neurons, zonisamide blocks the sustained firing of action potentials induced by depolarizing steps of current injected across the membrane.

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