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ChemicalBook >> CAS DataBase List >> 10-Hydroxycamptothecin

10-Hydroxycamptothecin

10-Hydroxycamptothecin price.
  • $16 - $1390
  • Product name: 10-Hydroxycamptothecin
  • CAS: 19685-09-7
  • MF: C20H16N2O5
  • MW: 364.35
  • EINECS:805-668-4
  • MDL Number:MFCD00189425
  • Synonyms:Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy ;hydroxy-camptotheci ;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
Price46 Properties Safety Information Description
46 prices
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Brand
  • Abosyn
  • AccelPharmtech
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AstaTech
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  • Cayman Chemical
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  • 10mM(in 1mL DMSO)
  • ManufacturerAbosyn
  • Product number61-3021
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98%
  • Packaging1g
  • Price$306
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberFB2418
  • Product description10-HydroxyCamptothecin 99%
  • Packaging5G
  • Price$310
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11456
  • Product description10-Hydroxycamptothecin
  • Packaging25mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11456
  • Product description10-Hydroxycamptothecin
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA155153
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA155153
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging250mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA155153
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging1g
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA155153
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging5g
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA155153
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging25g
  • Price$557
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4745
  • Product description(S)-10-Hydroxycamptothecin
  • Packaging25mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4745
  • Product description(S)-10-Hydroxycamptothecin
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4745
  • Product description(S)-10-Hydroxycamptothecin
  • Packaging100mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020342
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020342
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
  • Packaging250mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99735
  • Product description(S)-10-Hydroxycamptothecin ≥98%
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020342
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
  • Packaging1g
  • Price$55
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-3021 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98% 1g $306 2021-12-16 Buy
AccelPharmtech FB2418 10-HydroxyCamptothecin 99% 5G $310 2021-12-16 Buy
AK Scientific J11456 10-Hydroxycamptothecin 25mg $39 2021-12-16 Buy
AK Scientific J11456 10-Hydroxycamptothecin 100mg $98 2021-12-16 Buy
Ambeed A155153 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 100mg $16 2021-12-16 Buy
Ambeed A155153 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 250mg $30 2021-12-16 Buy
Ambeed A155153 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 1g $30 2021-12-16 Buy
Ambeed A155153 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 5g $56 2021-12-16 Buy
Ambeed A155153 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 25g $557 2021-12-16 Buy
ApexBio Technology B4745 (S)-10-Hydroxycamptothecin 25mg $40 2021-12-16 Buy
ApexBio Technology B4745 (S)-10-Hydroxycamptothecin 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology B4745 (S)-10-Hydroxycamptothecin 100mg $85 2021-12-16 Buy
Arctom AS020342 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% 100mg $16 2021-12-16 Buy
Arctom AS020342 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% 250mg $30 2021-12-16 Buy
Arctom CFN99735 (S)-10-Hydroxycamptothecin ≥98% 20mg $40 2021-12-16 Buy
Arctom AS020342 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% 1g $55 2021-12-16 Buy
Next Last

Properties

Melting point :265-270°C
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChI :InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
SMILES :N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.

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Suppliers and manufacturers

Shaanxi Xianhe Biotech Co., Ltd
10-Hydroxy camptothecin
$0.00 /1kg
10-Hydroxy camptothecin CAS:19685-09-7
career henan chemical co
10-Hydroxycamptothecin
$1.00 /1KG
10-Hydroxycamptothecin CAS:19685-09-7
NanJing Spring & Autumn Biological Engineering CO., LTD.
10-Hydroxycamptothecin 19685-09-7
$15.60 /20mg
10-Hydroxycamptothecin 19685-09-7 CAS:19685-09-7
Capot Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Shanghai Zheyan Biotech Co., Ltd.
Biochempartner
Chengdu Biopurify Phytochemicals Ltd.
Accela ChemBio Inc.
Shochem(Shanghai) Co.,Ltd