(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
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- $28 - $4766.8
- Product name: (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
- CAS: 128517-07-7
- MF: C24H36N4O6S2
- MW: 540.7
- EINECS:
- MDL Number:MFCD18433404
- Synonyms:FK 228;? FR 901228;? NSC 630176;? DEPSIPEPTIDE;FK228;CS-972;Romidisin;Romidepsin (FK228, Depsipeptide, FR1228);FK228 RoMidepsin;5)-disulfide;Cyclo[(2Z)-2-aMino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-Mercapto-4-heptenoyl-D-valyl-D-cysteinyl],cyclic (3®(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone RoMidepsin (FK228, Depsipeptide)
59 prices
Selected condition:
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- EvaluationSample
- 1unit
- 10mM(in 1mL DMSO)
- 10mM(in1mLDMSO)
- 1
- 10mM*1mLinDMSO
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- Manufactureraablocks
- Product numberAA000Y2K
- Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide ≥98%
- Packaging1mg
- Price$53
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Y2K
- Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99%
- Packaging5mg
- Price$130
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Y2K
- Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99%
- Packaging10mg
- Price$195
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Y2K
- Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide
- Packaging50mg
- Price$686
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Y2K
- Product descriptionCyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide
- Packaging100mg
- Price$916
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228574
- Product descriptionRomidepsin 97.00%
- Packaging100MG
- Price$820
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228574
- Product descriptionRomidepsin 97.00%
- Packaging5MG
- Price$200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228574
- Product descriptionRomidepsin 97.00%
- Packaging25MG
- Price$315
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5338
- Product descriptionRomidepsin
- Packaging10mg
- Price$628
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging10mg
- Price$942
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging250mg
- Price$1416
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging100mg
- Price$1416
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging1mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging5mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8173
- Product descriptionRomidepsin (FK228, depsipeptide)
- Packaging5mg
- Price$304
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8173
- Product descriptionRomidepsin(FK228,depsipeptide)
- Packaging10mM(in 1mL DMSO)
- Price$390
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000Y2K | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide ≥98% | 1mg | $53 | 2026-05-25 | Buy |
| aablocks | AA000Y2K | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99% | 5mg | $130 | 2026-05-25 | Buy |
| aablocks | AA000Y2K | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 99% | 10mg | $195 | 2026-05-25 | Buy |
| aablocks | AA000Y2K | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide | 50mg | $686 | 2026-05-25 | Buy |
| aablocks | AA000Y2K | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide | 100mg | $916 | 2026-05-25 | Buy |
| ACHEMBLOCK | Y228574 | Romidepsin 97.00% | 100MG | $820 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228574 | Romidepsin 97.00% | 5MG | $200 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228574 | Romidepsin 97.00% | 25MG | $315 | 2026-05-27 | Buy |
| AK Scientific | SYN5338 | Romidepsin | 10mg | $628 | 2021-12-16 | Buy |
| Ambeed | A380298 | Romidepsin 98+% | 10mg | $942 | 2021-12-16 | Buy |
| Ambeed | A380298 | Romidepsin 98+% | 250mg | $1416 | 2021-12-16 | Buy |
| Ambeed | A380298 | Romidepsin 98+% | 100mg | $1416 | 2021-12-16 | Buy |
| Ambeed | A380298 | Romidepsin 98+% | 1mg | $243 | 2021-12-16 | Buy |
| Ambeed | A380298 | Romidepsin 98+% | 5mg | $243 | 2021-12-16 | Buy |
| ApexBio Technology | A8173 | Romidepsin (FK228, depsipeptide) | 5mg | $304 | 2026-05-06 | Buy |
| ApexBio Technology | A8173 | Romidepsin(FK228,depsipeptide) | 10mM(in 1mL DMSO) | $390 | 2021-12-16 | Buy |
Properties
Melting point :219-224°C
Boiling point :942.8±65.0 °C(Predicted)
Density :1.174
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
pka :11.33±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :OHRURASPPZQGQM-RGTIDSFYNA-N
SMILES :[C@@]12([H])NC(=O)[C@@]([H])(C(C)C)NC(=O)C[C@@]([H])(C=CCCSSC1)OC(=O)[C@H](C(C)C)NC(=O)/C(=C/C)/NC2=O |c:16,&1:0,5,14,26,r|
Boiling point :942.8±65.0 °C(Predicted)
Density :1.174
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
pka :11.33±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :OHRURASPPZQGQM-RGTIDSFYNA-N
SMILES :[C@@]12([H])NC(=O)[C@@]([H])(C(C)C)NC(=O)C[C@@]([H])(C=CCCSSC1)OC(=O)[C@H](C(C)C)NC(=O)/C(=C/C)/NC2=O |c:16,&1:0,5,14,26,r|
Safety Information
| Symbol(GHS): |
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Description
Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent inhibition of HDACs 1, 2, 3, and 8 (IC50s = 53, 39, 53, and 26 nM, respectively), with less potency against HDACs 4, 6, 7, and 9 (IC50s = 470, 330, 3,200, and 12,000 nM, respectively). Through its effects on HDACs, romidepsin has anti-cancer activities, particularly against certain T cell lymphomas.More related product prices
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