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ChemicalBook >> CAS DataBase List >> 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid price.
  • $13 - $1900
  • Product name: 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • CAS: 1467057-23-3
  • MF: C19H16ClNO3
  • MW: 341.79
  • EINECS:
  • MDL Number:MFCD29917835
  • Synonyms:CS-2760;PF-06409577;PF 06409577;PF06409577;6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;PF-06409577;EOS-61684;PF 06409577;PF06409577;PF 6409577;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-
Price37 Properties Safety Information Description
37 prices
Selected condition：
Brand
  • A2B
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • 250mg
  • 50
  • 1G
  • 10mM*1mLinDMSO
  • ManufacturerA2B
  • Product numberAA64921
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99%
  • Packaging25mg
  • Price$62
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAA64921
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99%
  • Packaging10mg
  • Price$37
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAA64921
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99%
  • Packaging5mg
  • Price$26
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAA64921
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99%
  • Packaging1mg
  • Price$13
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA001E65
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98%
  • Packaging1mg
  • Price$14
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001E65
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98%
  • Packaging5mg
  • Price$29
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001E65
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98%
  • Packaging25mg
  • Price$69
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001E65
  • Product description1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98%
  • Packaging10mg
  • Price$42
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberU103396
  • Product descriptionPF-06409577 98.00%
  • Packaging25MG
  • Price$70
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberU103396
  • Product descriptionPF-06409577 98.00%
  • Packaging5MG
  • Price$30
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberU103396
  • Product descriptionPF-06409577 98.00%
  • Packaging100MG
  • Price$210
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberU103396
  • Product descriptionPF-06409577 98.00%
  • Packaging1G
  • Price$1250
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number5408DV
  • Product description6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5408DV
  • Product description6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4689
  • Product descriptionPF-06409577
  • Packaging5mg
  • Price$71
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4689
  • Product descriptionPF-06409577
  • Packaging10mg
  • Price$114
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A2B AA64921 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99% 25mg $62 2026-05-25 Buy
A2B AA64921 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99% 10mg $37 2026-05-25 Buy
A2B AA64921 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99% 5mg $26 2026-05-25 Buy
A2B AA64921 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 99% 1mg $13 2026-05-25 Buy
aablocks AA001E65 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98% 1mg $14 2026-05-28 Buy
aablocks AA001E65 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98% 5mg $29 2026-05-28 Buy
aablocks AA001E65 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98% 25mg $69 2026-05-28 Buy
aablocks AA001E65 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- 98% 10mg $42 2026-05-28 Buy
ACHEMBLOCK U103396 PF-06409577 98.00% 25MG $70 2026-05-27 Buy
ACHEMBLOCK U103396 PF-06409577 98.00% 5MG $30 2026-05-27 Buy
ACHEMBLOCK U103396 PF-06409577 98.00% 100MG $210 2026-05-27 Buy
ACHEMBLOCK U103396 PF-06409577 98.00% 1G $1250 2026-05-27 Buy
AK Scientific 5408DV 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 50mg $640 2021-12-16 Buy
AK Scientific 5408DV 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 10mg $218 2021-12-16 Buy
ApexBio Technology A4689 PF-06409577 5mg $71 2026-05-06 Buy
ApexBio Technology A4689 PF-06409577 10mg $114 2026-05-06 Buy
Next Last

Properties

Boiling point :610.9±55.0 °C(Predicted)
Density :1.468±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble
form :powder
pka :3.60±0.30(Predicted)
color :white to beige
InChI :InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
InChIKey :FHQXLWCFSUSXBF-UHFFFAOYSA-N
SMILES :N1C2=C(C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)C(C(O)=O)=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
PF-06409577
$61.00
PF-06409577 CAS:1467057-23-3
BOC Sciences
TargetMol Chemicals Inc.
HANGZHOU LEAP CHEM CO., LTD.
Aladdin Scientific
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Sichuan Yuehe Biopharmaceutical Co., Ltd ShangHai ChuanQian Chemcial Technique Centre Bide Pharmatech Ltd. Sichuan Yuehe Bio-Pharmaceutical Co.,Ltd