3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
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- $8 - $2229
- Product name: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
- CAS: 162401-62-9
- MF: C12H12F2O4
- MW: 258.22
- EINECS:605-288-7
- MDL Number:MFCD04621687
- Synonyms:3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid;Benzoic acid, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)-;CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID;3-CyclopropylMethoxy-4-isopropoxy-benzoic acid;RofluMilast InterMediate II;Roflumilast intermediate (3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid);Roflumilast Acid Impurity;3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, >=98%
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Brand
- aablocks
- AK Scientific
- Alichem
- Ambeed
- Apolloscientific
- Biosynth
- Chemcia Scientific
- Chemenu
- ChemScene
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- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
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Package
- 250mg
- 1g
- 5g
- 10g
- 25g
- 50g
- 100g
- 250g
- 500g
- Manufactureraablocks
- Product numberAA001SZK
- Product description3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98%
- Packaging250mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001SZK
- Product description3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98%
- Packaging1g
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001SZK
- Product description3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98%
- Packaging5g
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001SZK
- Product description3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98%
- Packaging10g
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001SZK
- Product description3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98%
- Packaging25g
- Price$85
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product numberJ97945
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95%
- Packaging10g
- Price$69
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberX3188
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC)
- Packaging5g
- Price$55
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberX3188
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC)
- Packaging10g
- Price$92
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ97945
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95%
- Packaging5g
- Price$41
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberX3188
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC)
- Packaging1g
- Price$16
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ97945
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95%
- Packaging1g
- Price$12
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ97945
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95%
- Packaging25g
- Price$154
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberX3188
- Product description3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC)
- Packaging25g
- Price$206
- Updated2026-06-04
- Buy
- ManufacturerAlichem
- Product number162401629
- Product description3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
- Packaging25g
- Price$196
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number162401629
- Product description3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
- Packaging100g
- Price$609
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA208015
- Product description3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 98%
- Packaging25g
- Price$200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001SZK | 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98% | 250mg | $8 | 2026-05-28 | Buy |
| aablocks | AA001SZK | 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98% | 1g | $10 | 2026-05-28 | Buy |
| aablocks | AA001SZK | 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98% | 5g | $18 | 2026-05-28 | Buy |
| aablocks | AA001SZK | 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98% | 10g | $34 | 2026-05-28 | Buy |
| aablocks | AA001SZK | 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzoic Acid 98% | 25g | $85 | 2026-05-28 | Buy |
| AK Scientific | J97945 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95% | 10g | $69 | 2026-06-04 | Buy |
| AK Scientific | X3188 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC) | 5g | $55 | 2026-06-04 | Buy |
| AK Scientific | X3188 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC) | 10g | $92 | 2026-06-04 | Buy |
| AK Scientific | J97945 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95% | 5g | $41 | 2026-06-04 | Buy |
| AK Scientific | X3188 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC) | 1g | $16 | 2026-06-04 | Buy |
| AK Scientific | J97945 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95% | 1g | $12 | 2026-06-04 | Buy |
| AK Scientific | J97945 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 95% | 25g | $154 | 2026-06-04 | Buy |
| AK Scientific | X3188 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 98%(HPLC) | 25g | $206 | 2026-06-04 | Buy |
| Alichem | 162401629 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid | 25g | $196 | 2021-12-16 | Buy |
| Alichem | 162401629 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid | 100g | $609 | 2021-12-16 | Buy |
| Ambeed | A208015 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 98% | 25g | $200 | 2021-12-16 | Buy |
Properties
Melting point :118-120℃
Boiling point :356.4±37.0 °C(Predicted)
Density :1.355±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.87±0.10(Predicted)
color :White to Off-White
InChI :InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey :IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-62-9
Boiling point :356.4±37.0 °C(Predicted)
Density :1.355±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.87±0.10(Predicted)
color :White to Off-White
InChI :InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey :IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-62-9
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).More related product prices
Roflumilast-d4 BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- Roflumilast 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde Roflumilast N-oxide D4 RofluMilast related substance N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide RofluMilast related substance RofluMilast N-Oxide 22889-78-7 RofluMilast related substance 228809-78-7 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMideRelated product price
Suppliers and manufacturers
Hefei TianRui Pharmaceutical Chemistry Co., Ltd.
Shanghai Famo Bio-chemical Technology Company Ltd.
Anhui Beirui Pharmaceutical Technology Co., Ltd
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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
J & K SCIENTIFIC LTD.
future industrial shanghai co., ltd
ZHIWE CHEMTECH CO LTD
Chembest Research Laboratories Limited
Alfa Aesar