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3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Structure
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid structure
CAS No.
162401-62-9
Chemical Name:
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
Synonyms
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid;RofluM;Roflumilast Impurity J;Roflumilast Impurity 33;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Acid Impurity of Roflumilast;Roflumilast Related Compound D;Roflumilast USP Related Compound D
CBNumber:
CB02487690
Molecular Formula:
C12H12F2O4
Molecular Weight:
258.22
MDL Number:
MFCD04621687
MOL File:
162401-62-9.mol
MSDS File:
SDS
Last updated:2026-06-23 18:03:16
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3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Properties

Melting point 118-120℃
Boiling point 356.4±37.0 °C(Predicted)
Density 1.355±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.87±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference 162401-62-9
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  2811
WGK Germany  WGK 3
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  2918999090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
NFPA 704
0
2 0

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000161 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9 1g $114 2026-04-30 Buy
TCI Chemical C3395 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid min. 98.0 % 162401-62-9 1G $89 2026-04-30 Buy
TCI Chemical C3395 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid min. 98.0 % 162401-62-9 5G $267 2026-04-30 Buy
Usbiological 269188 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Asreported 162401-62-9 5g $425 2026-06-03 Buy
Usbiological 269188 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Asreported 162401-62-9 10g $602 2026-06-03 Buy
Product number Packaging Price Buy
MNO000161 1g $114 Buy
C3395 1G $89 Buy
C3395 5G $267 Buy
269188 5g $425 Buy
269188 10g $602 Buy

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Chemical Properties,Uses,Production

Description

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) is a pharmaceutical intermediate ingredient used in the preparation of Roflumilast, a selective phosphodiesterase-4 (PDE4) inhibitor approved for the treatment of chronic bronchitis and to reduce the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).

Uses

An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).

Biological Activity

It was shown that 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) attenuated transforming growth factor-β1 (TGF-β1)-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. DGM treatment suppressed the expression of proteins such as α-SMA, waveform protein and collagen I and other proteins and increased the expression of E-cadherin. Correspondingly, the phosphorylation level of Smad2/3 was significantly reduced after DGM treatment[1].

Synthesis

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid is synthesised using 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde as raw material by chemical reaction. The specific synthesis steps are as follows:
3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (12 g, 50 mmol) and sulfamic acid (7.3 g, 75 mmol) were dissolved in glacial acetic acid (50 ml) and the solution added with a solution of sodium chlorite (8.2 g, 75 mmol) in water (15 ml). The reaction mixture was stirred at room temperature for 1 hr then water (300 ml) was added so obtaining the precipitation of a solid that was filtered and dried at 40° C. under vacuum (12 g, 48 mmol, 97percent yield).
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid synthesis

References

[1] TIANXIAO SUN. Inhibitory Effects of 3-Cyclopropylmethoxy-4-(difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial-Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo.[J]. International Journal of Molecular Sciences, 2023. DOI:10.3390/ijms24076172.

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Preparation Products And Raw materials

Raw materials

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde Benzene, 4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)- Carbon dioxide Sulfamic acid Sodium chlorite
Acetic acid

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Preparation Products

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Suppliers

Global( 285)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TianRui Pharmaceutical Chemistry Co., Ltd. 0551-68933033 13956024211 trchem@163.com China 99 58
Shanghai Famo Bio-chemical Technology Company Ltd. 02136680027 15800370750 1706640024@qq.com China 494 56
Anhui Beirui Pharmaceutical Technology Co., Ltd 0551-68665055 18130089676 ahbrchem@163.com China 18 58
Guangdong Shengke Biochemical Technology Co., Ltd. 18925113981 18925113981 3809205144@qq.com China 4069 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 022-60189726 18812034280 188120342808@163.com China 143 61
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399 zwchem@163.com China 529 61
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Hefei TianRui Pharmaceutical Chemistry Co., Ltd. 58
Shanghai Famo Bio-chemical Technology Company Ltd. 56
Anhui Beirui Pharmaceutical Technology Co., Ltd 58
Guangdong Shengke Biochemical Technology Co., Ltd. 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 61
J & K SCIENTIFIC LTD. 76
future industrial shanghai co., ltd 65
ZHIWE CHEMTECH CO LTD 61
Chembest Research Laboratories Limited 61
Alfa Aesar 84

View Lastest Price from 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid pictures 2026-06-30 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
162401-62-9
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid pictures 2025-12-05 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
162401-62-9
 5kg 99.99 1ton Hefei TianRui Pharmaceutical Chemical Co., Ltd.
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid pictures 2025-11-24 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
 1kg 99%min 100 KGS Hangzhou Verychem Science And Technology Co.Ltd

162401-62-9(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid)Related Search:

Roflumilast benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide Roflumilast-d4
RofluMilast N-Oxide RofluMilast related substance Roflumilast N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide 4-Amino-3,5-dichloropyridine N-oxide
RofluMilast related substance Roflumilast N-oxide D4 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast
4-Amino-3,5-dichloropyridine 3,5-Dichloro-4-aminopyridine 3,4-Bis-difluoromethoxy-benzaldehyde

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3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid Benzoic acid, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)- CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID 3-CyclopropylMethoxy-4-isopropoxy-benzoic acid RofluMilast InterMediate II Roflumilast intermediate (3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid) Roflumilast Acid Impurity 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, >=98% Roflumilast intermediate B Roflumilast Impurity J RofluM Roflumilast Carboxylic Acid Impurity Roflumilast Related Compound D Roflumilast USP Related Compound D Acid Impurity of Roflumilast Roflumilast Impurity 33 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 162401-62-9 C12H12O4F2 Roflumilast interemdiate Intermediates