N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide
![N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide price.](/CAS/GIF/487020-03-1.gif)
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- $38 - $2450
- Product name: N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide
- CAS: 487020-03-1
- MF: C20H11N5OS
- MW: 369.4
- EINECS:
- MDL Number:MFCD03286313
- Synonyms:N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide;HI-TOPK-32;N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide;HI-TOPK-032 (HI TOPK 032;2-Thiophenecarboxamide, N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)-;HITOPK032,inhibit,HI TOPK 032,TOPK,Inhibitor;HI-TOPK-032, 10 mM in DMSO;TOPK/PBK Inhibitor, HI-TOPK-032
26 prices
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Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5181
- Product descriptionHI-TOPK-32
- Packaging50mg
- Price$585
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5640
- Product descriptionHI TOPK 032
- Packaging50mg
- Price$586
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5640
- Product descriptionHI TOPK 032
- Packaging100mg
- Price$938
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5640
- Product descriptionHI TOPK 032
- Packaging5mg
- Price$101
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5640
- Product descriptionHI TOPK 032
- Packaging10mg
- Price$162
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5640
- Product descriptionHI TOPK 032
- Packaging25mg
- Price$342
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBISN0261
- Product descriptionHi topk 032
- Packaging25mg
- Price$259
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBISN0261
- Product descriptionHi topk 032
- Packaging10mg
- Price$123
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBISN0261
- Product descriptionHi topk 032
- Packaging5mg
- Price$82
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number19815
- Product descriptionHI TOPK 032 ≥95%
- Packaging1mg
- Price$38
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number19815
- Product descriptionHI TOPK 032 ≥95%
- Packaging5mg
- Price$102
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number19815
- Product descriptionHI TOPK 032 ≥95%
- Packaging10mg
- Price$165
- Updated2026-04-30
- Buy
- ManufacturerChemScene
- Product numberCS-6900
- Product descriptionHI-TOPK-032 98.31%
- Packaging25mg
- Price$278
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-6900
- Product descriptionHI-TOPK-032 98.31%
- Packaging50mg
- Price$479
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-6900
- Product descriptionHI-TOPK-032 98.31%
- Packaging10mg
- Price$129
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-6900
- Product descriptionHI-TOPK-032 98.31%
- Packaging5mg
- Price$86
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5181 | HI-TOPK-32 | 50mg | $585 | 2021-12-16 | Buy |
| ApexBio Technology | B5640 | HI TOPK 032 | 50mg | $586 | 2026-05-06 | Buy |
| ApexBio Technology | B5640 | HI TOPK 032 | 100mg | $938 | 2026-05-06 | Buy |
| ApexBio Technology | B5640 | HI TOPK 032 | 5mg | $101 | 2026-05-06 | Buy |
| ApexBio Technology | B5640 | HI TOPK 032 | 10mg | $162 | 2026-05-06 | Buy |
| ApexBio Technology | B5640 | HI TOPK 032 | 25mg | $342 | 2026-05-06 | Buy |
| Apolloscientific | BISN0261 | Hi topk 032 | 25mg | $259 | 2026-06-04 | Buy |
| Apolloscientific | BISN0261 | Hi topk 032 | 10mg | $123 | 2026-06-04 | Buy |
| Apolloscientific | BISN0261 | Hi topk 032 | 5mg | $82 | 2026-06-04 | Buy |
| Cayman Chemical | 19815 | HI TOPK 032 ≥95% | 1mg | $38 | 2026-04-30 | Buy |
| Cayman Chemical | 19815 | HI TOPK 032 ≥95% | 5mg | $102 | 2026-04-30 | Buy |
| Cayman Chemical | 19815 | HI TOPK 032 ≥95% | 10mg | $165 | 2026-04-30 | Buy |
| ChemScene | CS-6900 | HI-TOPK-032 98.31% | 25mg | $278 | 2026-06-04 | Buy |
| ChemScene | CS-6900 | HI-TOPK-032 98.31% | 50mg | $479 | 2026-06-04 | Buy |
| ChemScene | CS-6900 | HI-TOPK-032 98.31% | 10mg | $129 | 2026-06-04 | Buy |
| ChemScene | CS-6900 | HI-TOPK-032 98.31% | 5mg | $86 | 2026-06-04 | Buy |
Properties
Boiling point :415.3±45.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :9.32±0.46(Predicted)
form :powder
color :orange-brown
InChI :1S/C20H11N5OS/c21-11-13-16-10-12(22-20(26)17-6-3-9-27-17)7-8-25(16)19-18(13)23-14-4-1-2-5-15(14)24-19/h1-10H,(H,22,26)
InChIKey :BCSBXWKRZUPFHW-UHFFFAOYSA-N
SMILES :[s]1c(ccc1)C(=O)Nc2cc3[n](c4nc5c(nc4c3C#N)cccc5)cc2
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :9.32±0.46(Predicted)
form :powder
color :orange-brown
InChI :1S/C20H11N5OS/c21-11-13-16-10-12(22-20(26)17-6-3-9-27-17)7-8-25(16)19-18(13)23-14-4-1-2-5-15(14)24-19/h1-10H,(H,22,26)
InChIKey :BCSBXWKRZUPFHW-UHFFFAOYSA-N
SMILES :[s]1c(ccc1)C(=O)Nc2cc3[n](c4nc5c(nc4c3C#N)cccc5)cc2
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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Description
HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 μM and providing complete inhibition at 5 μM. It also inhibits checkpoint kinase 1 (Chk1; IC50 = 9.6 μM). In addition, HI TOPK 032 inhibits MEK1, achieving 40% inhibition at 5 μM, but it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 μM. HI TOPK 032 decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.Related product price
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487020-03-1
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Suppliers and manufacturers
Shaanxi Dideu New Materials Co. Ltd
Career Henan Chemica Co
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
J & K SCIENTIFIC LTD.
BOC Sciences
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Nanjing Dulai Biotechnology Co., Ltd.
HI-TOPK-032
CAS:487020-03-1