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ChemicalBook >> CAS DataBase List >> (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether

$55 - $3960
Product name: (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether
CAS: 848821-61-4
MF: C24H23F12NOSi
MW: 597.51
EINECS:
MDL Number:MFCD09750447
Synonyms:(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether;Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2S)-;(S)-α,α-BIS(3,5-BIS(TRIFLUOROMET;(S)-α,α-Bis[3,5-bis(trifluoroMethyl)phenyl]-2-pyrrolidineMethanol triMethylsilyl ether 97%;(S)-2-[(Bis(3,5-bis(trifluoroMethyl)phenyl)triMethylsilanyloxy)Methyl]pyrrolidine;(S)-α,α-[3,5-Bis(trifluoroMethyl)phenyl]prolinol triMethylsilyl ether;(S)-alpha,alpha-Bis[3,5-bis(trifluoroMethyl)phenyl]-2-pyrrolidineMethanol triMethylsilyl ether 97%;S-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triMethyl silyl)oxy]Methyl]-Pyrrolidine

Price19 Properties Safety Information Description

19 prices

Selected condition：

Brand

Alichem
American Custom Chemicals Corporation
Biosynth Carbosynth
Chemenu
Crysdot
JR MediChem
Matrix Scientific
Sigma-Aldrich
TCI Chemical
TRC

Package

100mg
250mg
500mg
1G
2g
2.5g
5g

ManufacturerAlichem
Product number848821614
Product description(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine
Packaging5g
Price$610
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberORS0001315
Product description(S)-ALPHA,ALPHA-BIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-PYRROLIDINEMETHANOL TRIMETHYLSILYL ETHER 97.00%
Packaging1G
Price$735.54
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberORS0001315
Product description(S)-ALPHA,ALPHA-BIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-PYRROLIDINEMETHANOL TRIMETHYLSILYL ETHER 97.00%
Packaging5G
Price$1130.28
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFB100522
Product description(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine
Packaging100mg
Price$55
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFB100522
Product description(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine
Packaging250mg
Price$90
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFB100522
Product description(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine
Packaging500mg
Price$140
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFB100522
Product description(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine
Packaging1g
Price$220
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFB100522
Product description(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine
Packaging2g
Price$350
Updated2021-12-16
Buy

ManufacturerChemenu
Product numberCM132747
Product description(S)-2-(bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine 95%
Packaging5g
Price$524
Updated2021-12-16
Buy

ManufacturerCrysdot
Product numberCD42000193
Product description(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine 95+%
Packaging1g
Price$203
Updated2021-12-16
Buy

ManufacturerCrysdot
Product numberCD42000193
Product description(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine 95+%
Packaging5g
Price$560
Updated2021-12-16
Buy

ManufacturerJR MediChem
Product numberJR6-L3913
Product descriptionPyrrolidine,2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-,(2S)- 96%
Packaging1g
Price$398
Updated2021-12-16
Buy

ManufacturerMatrix Scientific
Product number095213
Product description(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)-((trimethylsilyl)oxy)methyl)pyrrolidine 95%
Packaging1g
Price$1250
Updated2021-12-16
Buy

ManufacturerMatrix Scientific
Product number095213
Product description(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)-((trimethylsilyl)oxy)methyl)pyrrolidine 95%
Packaging5g
Price$3960
Updated2021-12-16
Buy

ManufacturerSigma-Aldrich
Product number677019
Product description(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether 97%
Packaging1g
Price$837
Updated2025-07-31
Buy

ManufacturerSigma-Aldrich
Product number677019
Product description(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether 97%
Packaging5g
Price$1015
Updated2025-07-31
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Alichem	848821614	(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine	5g	$610	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0001315	(S)-ALPHA,ALPHA-BIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-PYRROLIDINEMETHANOL TRIMETHYLSILYL ETHER 97.00%	1G	$735.54	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0001315	(S)-ALPHA,ALPHA-BIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-PYRROLIDINEMETHANOL TRIMETHYLSILYL ETHER 97.00%	5G	$1130.28	2021-12-16	Buy
Biosynth Carbosynth	FB100522	(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine	100mg	$55	2021-12-16	Buy
Biosynth Carbosynth	FB100522	(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine	250mg	$90	2021-12-16	Buy
Biosynth Carbosynth	FB100522	(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine	500mg	$140	2021-12-16	Buy
Biosynth Carbosynth	FB100522	(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine	1g	$220	2021-12-16	Buy
Biosynth Carbosynth	FB100522	(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl](trimethylsilyloxy)methyl]pyrrolidine	2g	$350	2021-12-16	Buy
Chemenu	CM132747	(S)-2-(bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine 95%	5g	$524	2021-12-16	Buy
Crysdot	CD42000193	(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine 95+%	1g	$203	2021-12-16	Buy
Crysdot	CD42000193	(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine 95+%	5g	$560	2021-12-16	Buy
JR MediChem	JR6-L3913	Pyrrolidine,2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-,(2S)- 96%	1g	$398	2021-12-16	Buy
Matrix Scientific	095213	(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)-((trimethylsilyl)oxy)methyl)pyrrolidine 95%	1g	$1250	2021-12-16	Buy
Matrix Scientific	095213	(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)-((trimethylsilyl)oxy)methyl)pyrrolidine 95%	5g	$3960	2021-12-16	Buy
Sigma-Aldrich	677019	(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether 97%	1g	$837	2025-07-31	Buy
Sigma-Aldrich	677019	(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether 97%	5g	$1015	2025-07-31	Buy

Next Last

Properties

Melting point :48-56 °C
Boiling point :382.4±37.0 °C(Predicted)
Density :1.319±0.06 g/cm3(Predicted)
Flash point :110 °C
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
pka :9.34±0.10(Predicted)
form :Solid
color :White to Off-White
InChIKey :MOHRGTBNEJKFMB-IBGZPJMESA-N
SMILES :C[Si](C)(C)OC([C@@H]1CCCN1)(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3cc(cc(c3)C(F)(F)F)C(F)(F)F

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.

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(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether

Properties

Safety Information

Description

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