ChemicalBook >> CAS DataBase List >>(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether structure

CAS No.: 848821-61-4

Chemical Name:: (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether

Synonyms: (S)-α,α-BIS(3,5-BIS(TRIFLUOROMET;Pyrrolidine,2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethy...;(S)-α,α-[3,5-Bis(trifluoroMethyl)phenyl]prolinol triMethylsilyl ether;(S)-2-[(Bis(3,5-bis(trifluoroMethyl)phenyl)triMethylsilanyloxy)Methyl]pyrrolidine;S-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triMethyl silyl)oxy]Methyl]-Pyrrolidine;(S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol;[bis[3,5-bis(trifluoromethyl)phenyl]-[(2S)-pyrrolidin-2-yl]methoxy]-trimethylsilane;(2S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]-[(trimethylsilyl)oxy]methyl]pyrrolidine;(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether;(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether

CBNumber:: CB72090844

Molecular Formula:: C24H23F12NOSi

Molecular Weight:: 597.51

MDL Number:: MFCD09750447

MOL File:: 848821-61-4.mol

MSDS File:: SDS

Last updated:2026-05-28 02:21:44

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(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether Properties

Melting point	48-56 °C
Boiling point	382.4±37.0 °C(Predicted)
Density	1.319±0.06 g/cm3(Predicted)
Flash point	110 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	9.34±0.10(Predicted)
color	White to Off-White
InChIKey	MOHRGTBNEJKFMB-IBGZPJMESA-N
SMILES	C[Si](C)(C)OC([C@@H]1CCCN1)(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3cc(cc(c3)C(F)(F)F)C(F)(F)F
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	677019	(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether 97%	848821-61-4	1g	$892	2026-04-30	Buy
Sigma-Aldrich	677019	(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether 97%	848821-61-4	5g	$2160	2026-04-30	Buy
TCI Chemical	B6611	(2S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]pyrrolidine min. 95.0 %	848821-61-4	1G	$211	2026-04-30	Buy
TRC	TRC-T303850-250MG	(S)-Alpha,Alpha-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol	848821-61-4	250mg	$124	2026-06-03	Buy
TRC	TRC-T303850-2.5G	(S)-Alpha,Alpha-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol	848821-61-4	2.5g	$774	2026-06-03	Buy

Product number	Packaging	Price	Buy
677019	1g	$892	Buy
677019	5g	$2160	Buy
B6611	1G	$211	Buy
TRC-T303850-250MG	250mg	$124	Buy
TRC-T303850-2.5G	2.5g	$774	Buy

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether Chemical Properties,Uses,Production

Uses

(S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.

General Description

(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether is a diarylprolinol silyl ether organocatalyst. It can catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Shanghai Holy Biohemdeviser Co., Ltd	021-61551100		China	443	57
Sci General Material & Chemical Ltd	021-58388037;21-58388037 13472507714	35177634@qq.com;1589045147@qq.com	China	795	55
Tianjin Derchemist Science & Technology Co., Ltd.	22-58627059 13920586291	zdcomcon@126.com	China	4094	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Infinity SCI	400-106-2016 17800804092	admin@infsci.com	China	471	55
Shanghai Chiral bio-compound co., Ltd.	021-5068 3667/17749785980/1029026415; 17749785980	1029026415@qq.com	China	4501	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
LaaJoo	021-60702684 18516024827	huang.jiayi@sinocompound.com	China	2280	58

Supplier	Advantage
Daicel Chiral Technologies (China)CO.,LTD	65
Shanghai Holy Biohemdeviser Co., Ltd	57
Sci General Material & Chemical Ltd	55
Tianjin Derchemist Science & Technology Co., Ltd.	50
Sigma-Aldrich	80
Infinity SCI	55
Shanghai Chiral bio-compound co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Amadis Chemical Company Limited	58
LaaJoo	58

848821-61-4((S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether)Related Search:

Pyrrolidine, 2-[bis(3,5-dimethylphenyl)[(trimethylsilyl)oxy]methyl]-, (2S)- Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)- (+)-FENFLURAMINE HYDROCHLORIDE 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol 3,3',5,5'-TETRAKIS(TRIFLUOROMETHYL)BENZHYDROL

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol flumecinol

3-(TRIFLUOROMETHYL)BENZHYDROL (S)-(-)-2-[Bis(3,5-dimethylphenyl)hydroxymethyl]pyrrolidine (S)-(-)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINYL METHYLTMS ETHER 3,3'-BIS(TRIFLUOROMETHYL)BENZHYDROL (S)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPAN-1-OL 2-Amino-1-[3-(trifluoromethyl)phenyl]ethanol (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine

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(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2S)- (S)-α,α-BIS(3,5-BIS(TRIFLUOROMET (S)-α,α-Bis[3,5-bis(trifluoroMethyl)phenyl]-2-pyrrolidineMethanol triMethylsilyl ether 97% (S)-2-[(Bis(3,5-bis(trifluoroMethyl)phenyl)triMethylsilanyloxy)Methyl]pyrrolidine (S)-α,α-[3,5-Bis(trifluoroMethyl)phenyl]prolinol triMethylsilyl ether (S)-alpha,alpha-Bis[3,5-bis(trifluoroMethyl)phenyl]-2-pyrrolidineMethanol triMethylsilyl ether 97% S-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triMethyl silyl)oxy]Methyl]-Pyrrolidine (2S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]-[(trimethylsilyl)oxy]methyl]pyrrolidine [bis[3,5-bis(trifluoromethyl)phenyl]-[(2S)-pyrrolidin-2-yl]methoxy]-trimethylsilane (S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol (S)-alpha,alpha-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether Pyrrolidine,2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethy... (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-2-[(Bis(3,5-Bis(TrifluoroMethyl)Phenyl)TriMethylsilanyloxy)Methyl]Pyrrolidine, (S)-2-[(Bis(3,5-Bis(TrifluoroMethyl)Phenyl)triMethylsilyloxy)Methyl]Pyrrolidine, (S)-α,α-[3,5-Bis(TrifluoroMethyl)Phe (S)-a,a-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol (>85%) 848821-61-4 C24H23F12NOSi