AZD 9668
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- $16 - $2986.9
- Product name: AZD 9668
- CAS: 848141-11-7
- MF: C25H22F3N5O4S
- MW: 545.53
- EINECS:
- MDL Number:MFCD26960961
- Synonyms:AZD 9668;AZD9668;AZD-9668;Avelestat (AZD9668);6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide;Avelestat;Alvelestat (AZD9668);1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-3-Pyridinecarboxamide
75 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 50.00mg
- 100.00mg
- 10mM*1mLinDMSO(Solution)
- 200mg
- 250.00mg
- 1g
- 10mM*1mLinDMSO
- 1000mg
- 10mM(in1mLDMSO)
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging50mg
- Price$96
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging100mg
- Price$134
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging250mg
- Price$235
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging10mg
- Price$37
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging5mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging2mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3KN
- Product descriptionAlvelestat 99%(HPLC)
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product number8535DG
- Product descriptionAlvelestat
- Packaging25mg
- Price$572
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8535DG
- Product descriptionAlvelestat
- Packaging5mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8535DG
- Product descriptionAlvelestat
- Packaging1mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1037
- Product descriptionAlvelestat
- Packaging10mM(in 1mL DMSO)
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1037
- Product descriptionAlvelestat
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1037
- Product descriptionAlvelestat
- Packaging25mg
- Price$187
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1037
- Product descriptionAlvelestat
- Packaging10mM(in1mLDMSO)
- Price$99
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1037
- Product descriptionAlvelestat
- Packaging10mg
- Price$121
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1037
- Product descriptionAlvelestat
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 50mg | $96 | 2026-05-28 | Buy |
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 100mg | $134 | 2026-05-28 | Buy |
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 250mg | $235 | 2026-05-28 | Buy |
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 10mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 5mg | $27 | 2026-05-28 | Buy |
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 2mg | $20 | 2026-05-28 | Buy |
| aablocks | AA00G3KN | Alvelestat 99%(HPLC) | 1mg | $16 | 2026-05-28 | Buy |
| AK Scientific | 8535DG | Alvelestat | 25mg | $572 | 2021-12-16 | Buy |
| AK Scientific | 8535DG | Alvelestat | 5mg | $218 | 2021-12-16 | Buy |
| AK Scientific | 8535DG | Alvelestat | 1mg | $147 | 2021-12-16 | Buy |
| ApexBio Technology | B1037 | Alvelestat | 10mM(in 1mL DMSO) | $156 | 2021-12-16 | Buy |
| ApexBio Technology | B1037 | Alvelestat | 10mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | B1037 | Alvelestat | 25mg | $187 | 2026-05-06 | Buy |
| ApexBio Technology | B1037 | Alvelestat | 10mM(in1mLDMSO) | $99 | 2026-05-06 | Buy |
| ApexBio Technology | B1037 | Alvelestat | 10mg | $121 | 2026-05-06 | Buy |
| ApexBio Technology | B1037 | Alvelestat | 5mg | $105 | 2021-12-16 | Buy |
Properties
Melting point :207-209°C
Boiling point :780.4±60.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly)
pka :11.00±0.20(Predicted)
form :Solid
color :White
Boiling point :780.4±60.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly)
pka :11.00±0.20(Predicted)
form :Solid
color :White
Safety Information
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Description
AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC50 = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC50s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.Related product price
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