AZD 9668
- CAS No.
- 848141-11-7
- Chemical Name:
- AZD 9668
- Synonyms
- Alvelestat;Cavosonstat;AZD9668;CS-1060;AZD 9668;AZD-9668;MPH-966);Avelestat;Alvelestat-13C,d3;Avelestat (AZD9668)
- CBNumber:
- CB02668624
- Molecular Formula:
- C25H22F3N5O4S
- Molecular Weight:
- 545.53
- MDL Number:
- MFCD26960961
- MOL File:
- 848141-11-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 207-209°C |
|---|---|
| Boiling point | 780.4±60.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 11.00±0.20(Predicted) |
| form | Solid |
| color | White |
| FDA UNII | 6Y5629322X |
| NCI Drug Dictionary | alvelestat |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
AZD 9668 price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26083 | AZD 9668 ≥95% | 848141-11-7 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 26083 | AZD 9668 ≥95% | 848141-11-7 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 26083 | AZD 9668 ≥95% | 848141-11-7 | 10mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 26083 | AZD 9668 ≥95% | 848141-11-7 | 25mg | $469 | 2026-04-30 | Buy |
| TRC | TRC-A794660-5MG | Avelestat | 848141-11-7 | 5mg | $186 | 2026-06-03 | Buy |
AZD 9668 Chemical Properties, Uses, Production
Description
AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC50 = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC50s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.
Uses
Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.
in vivo
Alvelestat (1-10 mg/kg; oral administration; twice daily; for 4 days; Female BALB/cJBomTac mice) treatment reduces the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1β[1].
| Animal Model: | Female BALB/cJBomTac mice exposed to smoke cigarette smoke[1] |
| Dosage: | 1 mg/kg , 3 mg/kg , 6 mg/kg , 10 mg/kg |
| Administration: | Oral administration; twice daily; for 4 days |
| Result: | Reduced the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1β. |
target
NE
References
[1] stevens t, ekholm k, gränse m, et al. azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. journal of pharmacology and experimental therapeutics, 2011, 339(1): 313-320.
AZD 9668 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from AZD 9668 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Alvelestat
848141-11-7
|
$30.00-54.00 | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Alvelestat
848141-11-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | Alvelestat
848141-11-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Alvelestat
848141-11-7
- $30.00-54.00
- 98.00%
- TargetMol Chemicals Inc.
-
- Alvelestat
848141-11-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Alvelestat
848141-11-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
