Afatinib dimaleate
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- $8 - $2200
- Product name: Afatinib dimaleate
- CAS: 850140-73-7
- MF: C28H29ClFN5O7
- MW: 602.02
- EINECS:810-416-1
- MDL Number:MFCD28969755
- Synonyms:BIBW2992-MA2;Afatinib (diMaleate);Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2);(2E)-N-(4-[(3-chloro-4-fluorophenyl)aMino]-7-{[(3S);Afatinib double Maleate;Afatinib (BIBW2992) Dimaleate;N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-(2E)-2-butenamide,(2Z)-2-butenedioate (1:2)
63 prices
Selected condition：
Brand
- A1 Biochem Labs
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 25mg
- 500mg
- 1000mg
- 200mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO
- 50
- 1.00g
- 5.00g
- 10
- 25.00g
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 10mM(in1mLDMSO)
- 5G
- 25g
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerA1 Biochem Labs
- Product number6566399
- Product descriptionAfatinib(dimaleate) 98%
- Packaging5G
- Price$450
- Updated2021-12-16
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging25g
- Price$718
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging10mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging50mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging100mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging250mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging1g
- Price$50
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging5g
- Price$162
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15408
- Product descriptionAfatinib dimaleate 98%
- Packaging100MG
- Price$160
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15408
- Product descriptionAfatinib dimaleate 98%
- Packaging1G
- Price$490
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15408
- Product descriptionAfatinib dimaleate 98%
- Packaging5G
- Price$1960
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3423AH
- Product descriptionAfatinibDimaleate
- Packaging250mg
- Price$159
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinib dimaleate
- Packaging5mg
- Price$53
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinibdimaleate
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinib dimaleate
- Packaging10mM(in1mLDMSO)
- Price$66
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6566399 | Afatinib(dimaleate) 98% | 5G | $450 | 2021-12-16 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 25g | $718 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 1mg | $8 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 10mg | $12 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 50mg | $15 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 100mg | $18 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 250mg | $22 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 1g | $50 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 5g | $162 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15408 | Afatinib dimaleate 98% | 100MG | $160 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15408 | Afatinib dimaleate 98% | 1G | $490 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15408 | Afatinib dimaleate 98% | 5G | $1960 | 2026-05-27 | Buy |
| AK Scientific | 3423AH | AfatinibDimaleate | 250mg | $159 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinib dimaleate | 5mg | $53 | 2026-05-06 | Buy |
| ApexBio Technology | A3145 | Afatinibdimaleate | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinib dimaleate | 10mM(in1mLDMSO) | $66 | 2026-05-06 | Buy |
Properties
Melting point :>237oC (dec.)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
Water Solubility :H2O: 2mg/mL, clear
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
Water Solubility :H2O: 2mg/mL, clear
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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| Precautionary statements: |
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Description
Afatinib dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites. While no manufacturing route has been disclosed to date, the most scalable published route likely derives from two Boehringer Ingelheim patents.More related product prices
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 162012-69-3 Afatinib (BIBW 2992) 86087-23-2 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Afatinib (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine trans-4-Dimethylaminocrotonic acid hydrochloride Olaparib Nintedanib Ethanesulfonate Salt PLERIXAFOR Crizotinib 918504-65-1Related product price
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4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
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Afatinib (BIBW 2992)
$10-2658.8
Suppliers and manufacturers
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