Welcome to chemicalbook!
China English Japan Germany
010-86108875
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structure Search
RFQ
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook Sign in

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook >> CAS DataBase List >> BAY-41-8543

BAY-41-8543

BAY-41-8543 price.
  • $28 - $2665
  • Product name: BAY-41-8543
  • CAS: 256498-66-5
  • MF: C21H21FN8O
  • MW: 420.44
  • EINECS:
  • MDL Number:MFCD18382081
  • Synonyms:BAY-41-8543;BAY-41-8543 Exclusive;BAY 41-8543 (BAY 418543);2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine;4,6-Pyrimidinediamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-;BAY 418543,vascular,systemic,antiplatelet,vasodilator,soluble,pulmonary,orally,nitric,beds,cardiovascular,BAY 41 8543,Guanylate Cyclase,Inhibitor,sGC,BAY 41-8543,oxide,inhibit;2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine;2-(1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)-5-morpholinopyrimidine-4,6-diamine
Price37 Properties Safety Information Description
37 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 2mg
  • 50
  • 10
  • 25mg
  • 50mg
  • 100mg
  • 1G
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543
  • Packaging25mg
  • Price$147
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543
  • Packaging50mg
  • Price$223
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543
  • Packaging100mg
  • Price$316
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543
  • Packaging10mg
  • Price$82
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543
  • Packaging5mg
  • Price$59
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543
  • Packaging2mg
  • Price$46
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE7A
  • Product descriptionBAY-41-8543 ≥98%
  • Packaging1mg
  • Price$28
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33265
  • Product descriptionBAY-41-8543 97%
  • Packaging1G
  • Price$2665
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33265
  • Product descriptionBAY-41-8543 97%
  • Packaging100MG
  • Price$530
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33265
  • Product descriptionBAY-41-8543 97%
  • Packaging25MG
  • Price$205
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33265
  • Product descriptionBAY-41-8543 97%
  • Packaging5MG
  • Price$80
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number4490CR
  • Product descriptionBAY 41-8543
  • Packaging5mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number4490CR
  • Product descriptionBAY 41-8543
  • Packaging25mg
  • Price$1305
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3639
  • Product descriptionBAY 41-8543
  • Packaging50mg
  • Price$1586
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3639
  • Product descriptionBAY 41-8543
  • Packaging1mg
  • Price$53
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3639
  • Product descriptionBAY 41-8543
  • Packaging5mg
  • Price$105
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00BE7A BAY-41-8543 25mg $147 2026-05-28 Buy
aablocks AA00BE7A BAY-41-8543 50mg $223 2026-05-28 Buy
aablocks AA00BE7A BAY-41-8543 100mg $316 2026-05-28 Buy
aablocks AA00BE7A BAY-41-8543 10mg $82 2026-05-28 Buy
aablocks AA00BE7A BAY-41-8543 5mg $59 2026-05-28 Buy
aablocks AA00BE7A BAY-41-8543 2mg $46 2026-05-28 Buy
aablocks AA00BE7A BAY-41-8543 ≥98% 1mg $28 2026-05-28 Buy
ACHEMBLOCK O33265 BAY-41-8543 97% 1G $2665 2026-05-27 Buy
ACHEMBLOCK O33265 BAY-41-8543 97% 100MG $530 2026-05-27 Buy
ACHEMBLOCK O33265 BAY-41-8543 97% 25MG $205 2026-05-27 Buy
ACHEMBLOCK O33265 BAY-41-8543 97% 5MG $80 2026-05-27 Buy
AK Scientific 4490CR BAY 41-8543 5mg $410 2021-12-16 Buy
AK Scientific 4490CR BAY 41-8543 25mg $1305 2021-12-16 Buy
ApexBio Technology C3639 BAY 41-8543 50mg $1586 2026-05-06 Buy
ApexBio Technology C3639 BAY 41-8543 1mg $53 2026-05-06 Buy
ApexBio Technology C3639 BAY 41-8543 5mg $105 2026-05-06 Buy
Next Last

Properties

Boiling point :599.7±50.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
solubility :DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
form :A crystalline solid
pka :5.18±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY-41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently up to 92-fold. Surprisingly, NO donors synergize with BAY-41-8543 in stimulating recombinant sGC. BAY-41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations. In vivo, BAY-41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. Inhalation of microparticles containing BAY-41-8543 increases pulmonary vasodilation without changing mean arterial pressure suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension.

More related product prices

BAY-41-8543 Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine

Related product price

Suppliers and manufacturers

Nanjing Chemlin Chemical Co., Ltd Shanghai XingMo Biotechnology Co., Ltd. Beijing Solarbio Science & Tecnology Co., Ltd. Amadis Chemical Company Limited BOC Sciences TargetMol Chemicals Inc. InvivoChem Career Henan Chemica Co Shanghai Kaiwei Chemical Technology Co., Ltd. Advanced chemblocks inc