BAY-41-8543
- CAS No.
- 256498-66-5
- Chemical Name:
- BAY-41-8543
- Synonyms
- BAY-41-8543;BAY-41-8543 Exclusive;BAY 41-8543 (BAY 418543);2-(1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)-5-morpholinopyrimidine-4,6-diamine;2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine;2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine;4,6-Pyrimidinediamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-;BAY 418543,vascular,systemic,antiplatelet,vasodilator,soluble,pulmonary,orally,nitric,beds,cardiovascular,BAY 41 8543,Guanylate Cyclase,Inhibitor,sGC,BAY 41-8543,oxide,inhibit
- CBNumber:
- CB32590331
- Molecular Formula:
- C21H21FN8O
- Molecular Weight:
- 420.44
- MDL Number:
- MFCD18382081
- MOL File:
- 256498-66-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 599.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.55±0.1 g/cm3(Predicted) |
| solubility | DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml |
| form | A crystalline solid |
| pka | 5.18±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 323T2C09SG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BAY-41-8543 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2727 | BAY 41-8543 ≥98% (HPLC) | 256498-66-5 | 5MG | $115 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2727 | BAY 41-8543 ≥98% (HPLC) | 256498-66-5 | 25MG | $464 | 2026-04-30 | Buy |
| Cayman Chemical | 10011131 | BAY 41-8543 ≥98% | 256498-66-5 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 10011131 | BAY 41-8543 ≥98% | 256498-66-5 | 5mg | $104 | 2026-04-30 | Buy |
| Cayman Chemical | 10011131 | BAY 41-8543 ≥98% | 256498-66-5 | 10mg | $165 | 2026-04-30 | Buy |
BAY-41-8543 Chemical Properties, Uses, Production
Uses
BAY 41-8543, is a Guanylyl cyclase (sGC) stimulator, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. BAY 41-8543 reduces pulmonary vascular resistance and protects right ventricular (RV)function. It also inhibits collagen-induced platelet aggregation, and promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. It has also shown Antihypertensive activity.
Definition
ChEBI: BAY-41-8543 is a pyrazolopyridine.
in vivo
BAY 41-8543 (10-100 μg/kg; IV) produces small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output[1].
BAY 41-8543 (0.003, 0.01, 0.03, 0.1, and 0.3mg/kg; iv) produces a dose-dependent and long-lasting decrease in blood pressure in anaesthetized rats. The blood pressure lowering effect of BAY 41-8543 lasts longer than the observation period of 30min. BAY 41-8543 (0.1, 0.3 and 1.0mgkg; oral) has maximal blood pressure lowering effects. The blood pressure lowering effects of the highest doses of BAY41-8543 lasts longer than the observation period of 120min[2].
BAY 41-8543 (3mg/kg; p.o.; twice daily; for 5 weeks) completely prevents the development of the increase in systolic blood pressure in 18-week-old renin transgenic rats (TGR(mRen2)27) on L-NAME treatment. BAY 41-8543 dramatically increases survival[2].
| Animal Model: | Adult male Sprague-Dawley rats weighing 325-450 g[1] |
| Dosage: | 10, 30, and 100 μg/kg |
| Administration: | IV |
| Result: | Produced small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output. |
storage
Store at -20°C
BAY-41-8543 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-41-8543 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 294 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49299 | 58 |
| Advanced chemblocks inc | 650-6922368 650-6922368;650-6922368 | sales@achemblock.com | China | 2988 | 58 |
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