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ChemicalBook >> CAS DataBase List >> CHIR-124

CHIR-124

CHIR-124 price.
  • $39 - $2841
  • Product name: CHIR-124
  • CAS: 405168-58-3
  • MF: C23H22ClN5O
  • MW: 419.91
  • EINECS:
  • MDL Number:MFCD18917220
  • Synonyms:CS-2141;CHIR-124 (CHIR124;CHIR-124;2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro-;4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one;CHIR-124 USP/EP/BP;Platelet-derived growth factor receptor,PDGFR,CHIR-124,Checkpoint Kinase (Chk),CD135,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,inhibit,Apoptosis,Inhibitor,FLT3;(S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one , CHIR-124
Price50 Properties Safety Information Description
50 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 5.00mg
  • 10mM(1mLinDMSO)
  • 2mg
  • 10.00mg
  • 2x5mg
  • 25.00mg
  • 250mg
  • 1g
  • 1mg
  • 10mM(in 1mL DMSO)
  • 5mg
  • 10mg
  • 25mg
  • 100mg
  • 10mM(in1mLDMSO)
  • 50mg
  • Manufactureraablocks
  • Product numberAA00C6CD
  • Product descriptionCHIR-124 ≥99%
  • Packaging1mg
  • Price$39
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C6CD
  • Product descriptionCHIR-124 98%
  • Packaging5mg
  • Price$51
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C6CD
  • Product descriptionCHIR-124 98%
  • Packaging10mg
  • Price$81
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C6CD
  • Product descriptionCHIR-124
  • Packaging25mg
  • Price$159
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C6CD
  • Product descriptionCHIR-124
  • Packaging50mg
  • Price$223
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C6CD
  • Product descriptionCHIR-124
  • Packaging100mg
  • Price$322
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY228763
  • Product descriptionCHIR-124 97.00%
  • Packaging100MG
  • Price$450
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY228763
  • Product descriptionCHIR-124 97.00%
  • Packaging25MG
  • Price$205
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2317AH
  • Product description(S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one
  • Packaging25mg
  • Price$478
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0032689
  • Product descriptionCHIR-124 95.00%
  • Packaging5MG
  • Price$503.36
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8394
  • Product descriptionCHIR-124
  • Packaging50mg
  • Price$420
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8394
  • Product descriptionCHIR-124
  • Packaging25mg
  • Price$250
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8394
  • Product descriptionCHIR-124
  • Packaging5mg
  • Price$88
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8394
  • Product descriptionCHIR-124
  • Packaging10mM(in 1mL DMSO)
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8394
  • Product descriptionCHIR-124
  • Packaging10mM(in1mLDMSO)
  • Price$95
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S2683
  • Product descriptionCHIR-124 99.48%
  • Packaging2mg
  • Price$67
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00C6CD CHIR-124 ≥99% 1mg $39 2026-05-28 Buy
aablocks AA00C6CD CHIR-124 98% 5mg $51 2026-05-28 Buy
aablocks AA00C6CD CHIR-124 98% 10mg $81 2026-05-28 Buy
aablocks AA00C6CD CHIR-124 25mg $159 2026-05-28 Buy
aablocks AA00C6CD CHIR-124 50mg $223 2026-05-28 Buy
aablocks AA00C6CD CHIR-124 100mg $322 2026-05-28 Buy
ACHEMBLOCK Y228763 CHIR-124 97.00% 100MG $450 2026-05-27 Buy
ACHEMBLOCK Y228763 CHIR-124 97.00% 25MG $205 2026-05-27 Buy
AK Scientific 2317AH (S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one 25mg $478 2021-12-16 Buy
American Custom Chemicals Corporation CHM0032689 CHIR-124 95.00% 5MG $503.36 2021-12-16 Buy
ApexBio Technology A8394 CHIR-124 50mg $420 2026-05-06 Buy
ApexBio Technology A8394 CHIR-124 25mg $250 2026-05-06 Buy
ApexBio Technology A8394 CHIR-124 5mg $88 2026-05-06 Buy
ApexBio Technology A8394 CHIR-124 10mM(in 1mL DMSO) $95 2021-12-16 Buy
ApexBio Technology A8394 CHIR-124 10mM(in1mLDMSO) $95 2026-05-06 Buy
Arctom SLK-S2683 CHIR-124 99.48% 2mg $67 2026-05-26 Buy
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Properties

Density :1.46
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming
form :solid
pka :9.00±0.70(Predicted)
color :Light yellow to brown
InChIKey :MOVBBVMDHIRCTG-LJQANCHMSA-N
SMILES :N1C2=C(C=C(Cl)C=C2)C(N[C@H]2C3CCN(CC3)C2)=C(C2NC3=CC=CC=C3N=2)C1=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 μM). In synergy with topoisomerase I poisons or ionizing radiation, CHIR124 can inhibit the growth of p53-mutant solid tumor cells both in vitro and in a xenograft model, potentiating tumor apoptosis.

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Suppliers and manufacturers

Hubei Kele Fine Chemical Co., Ltd Shanghai Boyle Chemical Co., Ltd. Jinan Trio PharmaTech Co., Ltd. Dalian Meilun Biotech Co., Ltd. Hangzhou Sage Chemical Co., Ltd. NCE Biomedical Co.,Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD AdooQ BioScience, LLC Shanghai Hekang Biotechnology Co., Ltd.