CUCURBITACIN I
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- $91 - $1798
- Product name: CUCURBITACIN I
- CAS: 2222-07-3
- MF: C30H42O7
- MW: 514.65
- EINECS:218-736-8
- MDL Number:MFCD09971044
- Synonyms:1,2-dehydroelatericina ;19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,9-methyl-2,16,20,2 ;JSI-124;2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione ;5-tetrahydroxy- ;cucurbitacine(i) ;ELATERICIN B;ELATERIN B
50 prices
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Brand
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mlx10mM(inDMSO)
- 2mg
- 10mM*1mLinDMSO(Solution)
- 20mg
- 1
- 50mg
- 100mg
- 1mg
- 5MG
- 10mM(in 1mL DMSO)
- 10mg
- 25MG
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- ManufacturerACHEMBLOCK
- Product numberV155770
- Product descriptionCucurbitacin I 98%
- Packaging5MG
- Price$215
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberV155770
- Product descriptionCucurbitacin I 98%
- Packaging25MG
- Price$445
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8596CN
- Product descriptionCucurbitacinI
- Packaging5mg
- Price$363
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0028941
- Product descriptionCUCURBITACIN I 95.00%
- Packaging5MG
- Price$1103.54
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacinI
- Packaging10mM(in 1mL DMSO)
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacin I
- Packaging10mg
- Price$683
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacin I
- Packaging10mM(in1mLDMSO)
- Price$495
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacin I
- Packaging5mg
- Price$502
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacin I
- Packaging1mg
- Price$118
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-N1405
- Product descriptionCucurbitacin I 99.56%
- Packaging1mg
- Price$91
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N1405
- Product descriptionCucurbitacin I 99.56%
- Packaging5mg
- Price$209
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N1405
- Product descriptionCucurbitacin I 99.56%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$226
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N1405
- Product descriptionCucurbitacin I 99.56%
- Packaging10mM*1mLinDMSO(Solution)
- Price$237
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N1405
- Product descriptionCucurbitacin I 99.56%
- Packaging25mg
- Price$428
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberAB0451
- Product descriptionCucurbitacin I 98%(HPLC)
- Packaging20mg
- Price$338
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N1405
- Product descriptionCucurbitacin I 99.56%
- Packaging10mg
- Price$276
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | V155770 | Cucurbitacin I 98% | 5MG | $215 | 2026-05-27 | Buy |
| ACHEMBLOCK | V155770 | Cucurbitacin I 98% | 25MG | $445 | 2026-05-27 | Buy |
| AK Scientific | 8596CN | CucurbitacinI | 5mg | $363 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0028941 | CUCURBITACIN I 95.00% | 5MG | $1103.54 | 2021-12-16 | Buy |
| ApexBio Technology | A4512 | CucurbitacinI | 10mM(in 1mL DMSO) | $470 | 2021-12-16 | Buy |
| ApexBio Technology | A4512 | Cucurbitacin I | 10mg | $683 | 2026-05-06 | Buy |
| ApexBio Technology | A4512 | Cucurbitacin I | 10mM(in1mLDMSO) | $495 | 2026-05-06 | Buy |
| ApexBio Technology | A4512 | Cucurbitacin I | 5mg | $502 | 2026-05-06 | Buy |
| ApexBio Technology | A4512 | Cucurbitacin I | 1mg | $118 | 2026-05-06 | Buy |
| Arctom | HY-N1405 | Cucurbitacin I 99.56% | 1mg | $91 | 2026-05-26 | Buy |
| Arctom | HY-N1405 | Cucurbitacin I 99.56% | 5mg | $209 | 2026-05-26 | Buy |
| Arctom | HY-N1405 | Cucurbitacin I 99.56% | 10mM*1mLinDMSO(Solid+Solvent) | $226 | 2026-05-26 | Buy |
| Arctom | HY-N1405 | Cucurbitacin I 99.56% | 10mM*1mLinDMSO(Solution) | $237 | 2026-05-26 | Buy |
| Arctom | HY-N1405 | Cucurbitacin I 99.56% | 25mg | $428 | 2026-05-26 | Buy |
| Arctom | AB0451 | Cucurbitacin I 98%(HPLC) | 20mg | $338 | 2026-05-26 | Buy |
| Arctom | HY-N1405 | Cucurbitacin I 99.56% | 10mg | $276 | 2026-05-26 | Buy |
Properties
Melting point :148-150°C
Boiling point :698.3±55.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
pka :8.51±0.70(Predicted)
form :solid
color :white to off-white
InChIKey :NISPVUDLMHQFRQ-KUIOOTTBNA-N
SMILES :[C@@]12(C)CC(O)C(C(O)(C)C(=O)/C=C/C(O)(C)C)[C@@]1(C)CC(=O)[C@]1(C)C3C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,17,22,35,r|
LogP :2.330 (est)
Boiling point :698.3±55.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
pka :8.51±0.70(Predicted)
form :solid
color :white to off-white
InChIKey :NISPVUDLMHQFRQ-KUIOOTTBNA-N
SMILES :[C@@]12(C)CC(O)C(C(O)(C)C(=O)/C=C/C(O)(C)C)[C@@]1(C)CC(=O)[C@]1(C)C3C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,17,22,35,r|
LogP :2.330 (est)
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulting in inhibition of STAT3 DNA binding and reduced STAT3-mediated gene transcription. It also suppresses JAK2 phosphorylation but does not affect Src, ERK, JNK or Akt. In nude mice, cucurbitacin I(1 mg/kg/day) suppressed growth of various tumors expressing constitutively active STAT3. It promotes the differentiation of dendritic cells and macrophages and enhances the effect of cancer immunotherapy. Cucubitacin I (1 μM for 2 hours) reduced clonogenicity of nasopharyngeal carcinoma cells in vitro and suppresses tumor growth in mice (1.3 mg/kg).
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Suppliers and manufacturers
Jiaozuo Furuitang Pharmaceutical Co., Ltd.
Chengdu Bioanseis Phytochemicals Co., Ltd.
J & K SCIENTIFIC LTD.
Meryer (Shanghai) Chemical Technology Co., Ltd.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chengdu Biopurify Phytochemicals Ltd.
Shanghai Winherb Medical Technology Co., Ltd.
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
AdooQ BioScience, LLC