- Cucurbitacin I
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- $77.00 / 1mg
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2026-01-12
- CAS:2222-07-3
- Min. Order:
- Purity: 99.73%
- Supply Ability: 10g
- CUCURBITACIN I
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- $1.00 / 1KG
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2019-07-06
- CAS:2222-07-3
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
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| | CUCURBITACIN I Basic information |
| Product Name: | CUCURBITACIN I | | Synonyms: | 1,2-dehydroelatericina;19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,9-methyl-2,16,20,2;JSI-124;2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione;5-tetrahydroxy-;cucurbitacine(i);ELATERICIN B;ELATERIN B | | CAS: | 2222-07-3 | | MF: | C30H42O7 | | MW: | 514.65 | | EINECS: | 218-736-8 | | Product Categories: | Inhibitor;Herb extract;API;Tri-Terpenoids | | Mol File: | 2222-07-3.mol |  |
| | CUCURBITACIN I Chemical Properties |
| Melting point | 148-150°C | | Boiling point | 698.3±55.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | ≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic | | form | solid | | pka | 8.51±0.70(Predicted) | | color | white to off-white | | InChIKey | NISPVUDLMHQFRQ-KUIOOTTBNA-N | | SMILES | [C@@]12(C)CC(O)C(C(O)(C)C(=O)/C=C/C(O)(C)C)[C@@]1(C)CC(=O)[C@]1(C)C3C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,17,22,35,r| | | LogP | 2.330 (est) |
| Hazard Codes | Xi,T+ | | Risk Statements | 25-28 | | Safety Statements | 1-22-45-36/37-28 | | RIDADR | UN 2811 6.1/PG 1 | | WGK Germany | 3 | | RTECS | RC6200000 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 1 Oral | | Toxicity | LD50 oral in mouse: 5mg/kg |
| | CUCURBITACIN I Usage And Synthesis |
| Description | Cucurbitacin I is a naturally occurring tetracyclic triterpenoid compound with a variety of physiological effects, including induction of apoptosis and blockade of cell cycle progression in various cancer cells. It has also been shown to have anti-angiogenic activity. Cucurbitacin I inhibits the phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. Therefore, Cucurbitacin I is considered a potential angiogenesis inhibitor candidate for cancer therapy[1]. | | Uses | Cucurbitacin I can be useful in the study of edible vitalmelon fruit extract and adipogenesis. | | Definition | ChEBI: Cucurbitacin I is a cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. It has a role as a plant metabolite and an antineoplastic agent. It is a cucurbitacin and a tertiary alpha-hydroxy ketone. | | Biological Activity | Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. | | Biochem/physiol Actions | Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties. | | storage | Store at -20°C | | References | [1] HYEON JIN KIM Jin K K. Antiangiogenic effects of cucurbitacin-I[J]. Archives of Pharmacal Research, 2014. DOI:10.1007/s12272-014-0386-5.
blaskovich ma, sun j, cantor a et al. discovery of jsi-124 (cucurbitacin i), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.cancer res. 2003 mar 15;63(6):1270-9.yu h, lee h, herrmann a et al. revisiting stat3 signalling in cancer: new and unexpected biological functions.nat rev cancer. 2014 nov;14(11):736-46. doi: 10.1038/nrc3818.song j, liu h, li z et al. cucurbitacin i inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. oncol rep. 2015 apr;33(4):1867-71. qi j, xia g, huang cr et al. jsi-124 (cucurbitacin i) inhibits tumor angiogenesis of human breast cancer through reduction of stat3 phosphorylation. am j chin med. 2015;43(2):337-47.kim hj, kim jk et al. antiangiogenic effects of cucurbitacin-i. arch pharm res. 2015 feb;38(2):290-8. yuan g, yan sf, xue h et al. cucurbitacin i induces protective autophagy in glioblastoma in vitro and in vivo. j biol chem. 2014 apr 11;289(15):10607-19. |
| | CUCURBITACIN I Preparation Products And Raw materials |
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