Encorafenib (LGX818)
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- $41 - $5210.5
- Product name: Encorafenib (LGX818)
- CAS: 1269440-17-6
- MF: C22H27ClFN7O4S
- MW: 540.01
- EINECS:
- MDL Number:MFCD25976758
- Synonyms:LGX 818;CS-1037;methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate;Encorafenib (LGX818);Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester;LGX 818 (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;LGX818, >=98%;LGX 818; LGX-818;LGX818
54 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 500μg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 500ug
- 0.5mg
- 1mg
- 10mM*1mLinDMSO
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA000WCF
- Product description(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98
- Packaging1mg
- Price$58
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WCF
- Product description(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98%
- Packaging10mg
- Price$87
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WCF
- Product description(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98%
- Packaging25mg
- Price$145
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000WCF
- Product description(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98%
- Packaging50mg
- Price$261
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8721
- Product descriptionEncorafenib 98%
- Packaging25MG
- Price$150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8721
- Product descriptionEncorafenib 98%
- Packaging5MG
- Price$65
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8721
- Product descriptionEncorafenib 98%
- Packaging100MG
- Price$395
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8721
- Product descriptionEncorafenib 98%
- Packaging1G
- Price$1550
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberY1910
- Product descriptionLGX-818
- Packaging2mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0018401
- Product descriptionLGX-818 95.00%
- Packaging5MG
- Price$495.87
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0018401
- Product descriptionLGX-818 95.00%
- Packaging1MG
- Price$305.55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1174
- Product descriptionLGX818
- Packaging1mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1174
- Product descriptionLGX818
- Packaging5mg
- Price$114
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberBD-A312190
- Product descriptionEncorafenib 98%
- Packaging10mg
- Price$90
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberBD-A312190
- Product descriptionEncorafenib 98%
- Packaging25mg
- Price$149
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15605
- Product descriptionEncorafenib 99.83%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$150
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000WCF | (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98 | 1mg | $58 | 2026-05-25 | Buy |
| aablocks | AA000WCF | (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98% | 10mg | $87 | 2026-05-25 | Buy |
| aablocks | AA000WCF | (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98% | 25mg | $145 | 2026-05-25 | Buy |
| aablocks | AA000WCF | (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate 98% | 50mg | $261 | 2026-05-25 | Buy |
| ACHEMBLOCK | H-8721 | Encorafenib 98% | 25MG | $150 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8721 | Encorafenib 98% | 5MG | $65 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8721 | Encorafenib 98% | 100MG | $395 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8721 | Encorafenib 98% | 1G | $1550 | 2026-05-27 | Buy |
| AK Scientific | Y1910 | LGX-818 | 2mg | $225 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0018401 | LGX-818 95.00% | 5MG | $495.87 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0018401 | LGX-818 95.00% | 1MG | $305.55 | 2021-12-16 | Buy |
| ApexBio Technology | B1174 | LGX818 | 1mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | B1174 | LGX818 | 5mg | $114 | 2026-05-06 | Buy |
| Arctom | BD-A312190 | Encorafenib 98% | 10mg | $90 | 2026-05-26 | Buy |
| Arctom | BD-A312190 | Encorafenib 98% | 25mg | $149 | 2026-05-26 | Buy |
| Arctom | HY-15605 | Encorafenib 99.83% | 10mM*1mLinDMSO(Solid+Solvent) | $150 | 2026-05-26 | Buy |
Properties
Melting point :184-185°C
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White
InChIKey :CMJCXYNUCSMDBY-ZDUSSCGKSA-N
SMILES :C(OC)(=O)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C2=CC(Cl)=CC(NS(C)(=O)=O)=C2F)=N1
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White
InChIKey :CMJCXYNUCSMDBY-ZDUSSCGKSA-N
SMILES :C(OC)(=O)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C2=CC(Cl)=CC(NS(C)(=O)=O)=C2F)=N1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma. Encorafenib is a selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.Related product price
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