Dabrafenib
|
- $9 - $5400
- Product name: Dabrafenib
- CAS: 1195765-45-7
- MF: C23H20F3N5O2S2
- MW: 519.56
- EINECS:689-166-9
- MDL Number:MFCD17215684
- Synonyms:Dabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib free base(GSK2118436A);Dabrafenib (GSK2118436);GSK2118436A;Dabrafenib (GSK2118436A);CS-658;N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
42 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- SynChem
- TRC
Package
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 5g
- 100 mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberJ96885
- Product descriptionDabrafenib
- Packaging500mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1871
- Product descriptionDabrafenib
- Packaging1g
- Price$1001
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging1mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging5mg
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging10mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging50mg
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging100mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging250mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging1g
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1407
- Product descriptionDabrafenib(GSK2118436)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1407
- Product descriptionDabrafenib(GSK2118436)
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1407
- Product descriptionDabrafenib(GSK2118436)
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0192
- Product descriptionDabrafenib
- Packaging1mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0192
- Product descriptionDabrafenib
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0192
- Product descriptionDabrafenib
- Packaging10mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60005
- Product descriptionDabrafenib ≥98%
- Packaging20mg
- Price$168
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J96885 | Dabrafenib | 500mg | $390 | 2021-12-16 | Buy |
| AK Scientific | Y1871 | Dabrafenib | 1g | $1001 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 1mg | $9 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 5mg | $15 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 10mg | $20 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 50mg | $34 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 100mg | $44 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 250mg | $87 | 2021-12-16 | Buy |
| Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 1g | $218 | 2021-12-16 | Buy |
| ApexBio Technology | B1407 | Dabrafenib(GSK2118436) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| ApexBio Technology | B1407 | Dabrafenib(GSK2118436) | 10mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | B1407 | Dabrafenib(GSK2118436) | 50mg | $150 | 2021-12-16 | Buy |
| Apolloscientific | BISN0192 | Dabrafenib | 1mg | $54 | 2021-12-16 | Buy |
| Apolloscientific | BISN0192 | Dabrafenib | 5mg | $82 | 2021-12-16 | Buy |
| Apolloscientific | BISN0192 | Dabrafenib | 10mg | $115 | 2021-12-16 | Buy |
| Arctom | CFN60005 | Dabrafenib ≥98% | 20mg | $168 | 2021-12-16 | Buy |
Properties
Melting point :214-216oC
Boiling point :653.7±65.0 °C(Predicted)
Density :1.443
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
form :White solid.
pka :6.62±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES :C1(S(NC2=CC=CC(C3=C(C4C=CN=C(N)N=4)SC(C(C)(C)C)=N3)=C2F)(=O)=O)=C(F)C=CC=C1F
Boiling point :653.7±65.0 °C(Predicted)
Density :1.443
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
form :White solid.
pka :6.62±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES :C1(S(NC2=CC=CC(C3=C(C4C=CN=C(N)N=4)SC(C(C)(C)C)=N3)=C2F)(=O)=O)=C(F)C=CC=C1F
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively). It has been investigated in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors and is often combined with the MEK inhibitor trametinib to circumvent the development of B-Raf inhibitor resistance.Related product price
- 918504-65-1
$29-3960 - Crizotinib
$5-1963.5 - Ibrutinib
$5-1208.7
Suppliers and manufacturers
career henan chemical co
![N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide](https://img.chemicalbook.com/ProductImageEN/2018-8/small/639db4b1-b54a-4fa2-bda0-303e3445dcb7.gif)
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
$1.00 /1KG
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide CAS:1195765-45-7
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide CAS:1195765-45-7