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ChemicalBook >> CAS DataBase List >> JH-II-127

JH-II-127

JH-II-127 price.
  • $36 - $2989
  • Product name: JH-II-127
  • CAS: 1700693-08-8
  • MF: C19H21ClN6O3
  • MW: 416.86
  • EINECS:
  • MDL Number:MFCD28975160
  • Synonyms:JH-II-127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
Price37 Properties Safety Information Description
37 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 50
  • 1mg
  • 2mg
  • 10mM*1mLinDMSO
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250MG
  • 1g
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone ≥98%
  • Packaging1mg
  • Price$36
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 98+%
  • Packaging2mg
  • Price$49
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 98+%
  • Packaging5mg
  • Price$60
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
  • Packaging10mg
  • Price$103
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
  • Packaging25mg
  • Price$163
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
  • Packaging50mg
  • Price$250
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00ABLD
  • Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
  • Packaging100mg
  • Price$346
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32843
  • Product descriptionJH-II-127 98%
  • Packaging100MG
  • Price$485
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32843
  • Product descriptionJH-II-127 98%
  • Packaging250MG
  • Price$970
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number5830EE
  • Product descriptionCID112499966
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth
  • Product numberATC69308
  • Product descriptionJH-II-127
  • Packaging25mg
  • Price$1342.75
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberATC69308
  • Product descriptionJH-II-127
  • Packaging50mg
  • Price$1868
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberATC69308
  • Product descriptionJH-II-127
  • Packaging100mg
  • Price$2989
  • Updated2026-06-04
  • Buy
  • ManufacturerCayman Chemical
  • Product number22905
  • Product descriptionJH-II-127 ≥98%
  • Packaging1mg
  • Price$36
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number22905
  • Product descriptionJH-II-127 ≥98%
  • Packaging25mg
  • Price$587
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number22905
  • Product descriptionJH-II-127 ≥98%
  • Packaging5mg
  • Price$153
  • Updated2026-04-30
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone ≥98% 1mg $36 2026-05-28 Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 98+% 2mg $49 2026-05-28 Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 98+% 5mg $60 2026-05-28 Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 10mg $103 2026-05-28 Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 25mg $163 2026-05-28 Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 50mg $250 2026-05-28 Buy
aablocks AA00ABLD (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 100mg $346 2026-05-28 Buy
ACHEMBLOCK O32843 JH-II-127 98% 100MG $485 2026-05-27 Buy
ACHEMBLOCK O32843 JH-II-127 98% 250MG $970 2026-05-27 Buy
AK Scientific 5830EE CID112499966 1mg $133 2021-12-16 Buy
Biosynth ATC69308 JH-II-127 25mg $1342.75 2026-06-04 Buy
Biosynth ATC69308 JH-II-127 50mg $1868 2026-06-04 Buy
Biosynth ATC69308 JH-II-127 100mg $2989 2026-06-04 Buy
Cayman Chemical 22905 JH-II-127 ≥98% 1mg $36 2026-04-30 Buy
Cayman Chemical 22905 JH-II-127 ≥98% 25mg $587 2026-04-30 Buy
Cayman Chemical 22905 JH-II-127 ≥98% 5mg $153 2026-04-30 Buy
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Properties

Melting point :>166°C (dec.)
Density :1.458±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.49±0.50(Predicted)
form :Solid
color :White to Pale Beige
InChI :1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)
InChIKey :HUEKBQXFNHWTQQ-UHFFFAOYSA-N
SMILES :Clc1c2c(nc([nH]c2NC)Nc3c(cc(cc3)C(=O)N4CCOCC4)OC)nc1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. BOC Sciences Haoyuan Chemexpress Co., Ltd. UHN Shanghai Research & Development Co., Ltd. AdooQ Bioscience CHINA Shanghai Lollane Biological Technology Co.,Ltd. Shanghaizehan biopharma technology co., Ltd. ShangHai Siyan Biological Technology Co., Ltd. Guangzhou QiYun Biotechnology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd.