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ChemicalBook >> CAS DataBase List >> LY411575

LY411575

$34 - $4023.9
Product name: LY411575
CAS: 209984-57-6
MF: C26H23F2N3O4
MW: 479.48
EINECS:
MDL Number:MFCD09832551
Synonyms:LY411575;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide;(S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide;Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575;LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide;LSN-411575;N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide

Price66 Properties Safety Information Description

66 prices

Selected condition：

Brand

aablocks
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Ark Pharm
Biorbyt Ltd
Biosynth
Cayman Chemical
ChemScene
Crysdot
CSNpharm
DC Chemicals
Matrix Scientific
Sigma-Aldrich
TCI Chemical
Usbiological

Package

10mM(1mLinDMSO)
250mg
10mM(in 1mL DMSO)
50.00mg
100.00mg
1g
10mM*1mLinDMSO
1000mg
10mM(in1mLDMSO)
0.5MG
1mg
2mg
5mg
10mg
25mg
50mg
100mg

Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98%
Packaging1mg
Price$34
Updated2026-05-28
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Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98
Packaging2mg
Price$51
Updated2026-05-28
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Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98
Packaging5mg
Price$69
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98%
Packaging10mg
Price$70
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98%
Packaging25mg
Price$92
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98%
Packaging50mg
Price$155
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA002KFF
Product descriptionLY411575 98%
Packaging100mg
Price$261
Updated2026-05-28
Buy

ManufacturerAK Scientific
Product number2530AH
Product description(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide
Packaging5mg
Price$132
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2530AH
Product description(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide
Packaging10mg
Price$170
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA140795
Product descriptionLY411575 98+%
Packaging50mg
Price$178
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA140795
Product descriptionLY411575 98+%
Packaging25mg
Price$137
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA140795
Product descriptionLY411575 98+%
Packaging10mg
Price$82
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA140795
Product descriptionLY411575 98+%
Packaging5mg
Price$54
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA140795
Product descriptionLY411575 98+%
Packaging100mg
Price$241
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013693
Product description(AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00%
Packaging0.5MG
Price$407.76
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013693
Product description(AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00%
Packaging1MG
Price$415.52
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA002KFF	LY411575 98%	1mg	$34	2026-05-28	Buy
aablocks	AA002KFF	LY411575 98	2mg	$51	2026-05-28	Buy
aablocks	AA002KFF	LY411575 98	5mg	$69	2026-05-28	Buy
aablocks	AA002KFF	LY411575 98%	10mg	$70	2026-05-28	Buy
aablocks	AA002KFF	LY411575 98%	25mg	$92	2026-05-28	Buy
aablocks	AA002KFF	LY411575 98%	50mg	$155	2026-05-28	Buy
aablocks	AA002KFF	LY411575 98%	100mg	$261	2026-05-28	Buy
AK Scientific	2530AH	(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide	5mg	$132	2021-12-16	Buy
AK Scientific	2530AH	(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide	10mg	$170	2021-12-16	Buy
Ambeed	A140795	LY411575 98+%	50mg	$178	2021-12-16	Buy
Ambeed	A140795	LY411575 98+%	25mg	$137	2021-12-16	Buy
Ambeed	A140795	LY411575 98+%	10mg	$82	2021-12-16	Buy
Ambeed	A140795	LY411575 98+%	5mg	$54	2021-12-16	Buy
Ambeed	A140795	LY411575 98+%	100mg	$241	2021-12-16	Buy
American Custom Chemicals Corporation	API0013693	(AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00%	0.5MG	$407.76	2021-12-16	Buy
American Custom Chemicals Corporation	API0013693	(AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00%	1MG	$415.52	2021-12-16	Buy

Next Last

Properties

Boiling point :836.0±65.0 °C(Predicted)
Density :1.40
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear
pka :11.79±0.20(Predicted)
form :powder
color :white to beige
InChIKey :ULSSJYNJIZWPSB-CVRXJBIPSA-N
SMILES :C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning		P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Jinan Trio PharmaTech Co., Ltd. Spectrum Chemical Manufacturing Corp. Dalian Meilun Biotech Co., Ltd. NCE Biomedical Co.,Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD shanghai cooperpharm co.,LTD . AdooQ BioScience, LLC

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LY411575

Properties

Safety Information

Description

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