RQ-00203078
|
- $16 - $1800
- Product name: RQ-00203078
- CAS: 1254205-52-1
- MF: C21H13ClF6N2O5S
- MW: 554.85
- EINECS:
- MDL Number:MFCD29049510
- Synonyms:RQ-00203078;RQ 00203078;RQ00203078.;CS-1528;4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid;RQ-00203078;4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid;Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-;RQ-00203078 >=98% (HPLC);Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol
43 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10.00mg
- 50.00mg
- 10mM*1mLinDMSO(Solution)
- 100.00mg
- 1g
- 10
- 5 mg
- 25 mg
- 50
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 25MG
- 50mg
- 250MG
- 10mM(in1mLDMSO)
- 100mg
- Manufactureraablocks
- Product numberAA009CHD
- Product descriptionRQ 00203078 99%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CHD
- Product descriptionRQ 00203078 99%
- Packaging5mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CHD
- Product descriptionRQ 00203078 99%
- Packaging10mg
- Price$45
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CHD
- Product descriptionRQ 00203078 99
- Packaging50mg
- Price$178
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CHD
- Product descriptionRQ 00203078 99
- Packaging100mg
- Price$316
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230528
- Product descriptionRQ-00203078 98%
- Packaging100MG
- Price$440
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230528
- Product descriptionRQ-00203078 98%
- Packaging25MG
- Price$150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230528
- Product descriptionRQ-00203078 98%
- Packaging250MG
- Price$880
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3074DH
- Product descriptionCID49783953
- Packaging10mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5872
- Product descriptionRQ-00203078
- Packaging50mg
- Price$275
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5872
- Product descriptionRQ-00203078
- Packaging10mg
- Price$99
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5872
- Product descriptionRQ-00203078
- Packaging10mM(in 1mL DMSO)
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5872
- Product descriptionRQ-00203078
- Packaging10mM(in1mLDMSO)
- Price$110
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-18662
- Product descriptionRQ-00203078 99.62%
- Packaging5mg
- Price$53
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18662
- Product descriptionRQ-00203078 99.62%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$61
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18662
- Product descriptionRQ-00203078 99.62%
- Packaging10mM*1mLinDMSO(Solution)
- Price$64
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CHD | RQ 00203078 99% | 1mg | $16 | 2026-05-28 | Buy |
| aablocks | AA009CHD | RQ 00203078 99% | 5mg | $31 | 2026-05-28 | Buy |
| aablocks | AA009CHD | RQ 00203078 99% | 10mg | $45 | 2026-05-28 | Buy |
| aablocks | AA009CHD | RQ 00203078 99 | 50mg | $178 | 2026-05-28 | Buy |
| aablocks | AA009CHD | RQ 00203078 99 | 100mg | $316 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y230528 | RQ-00203078 98% | 100MG | $440 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y230528 | RQ-00203078 98% | 25MG | $150 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y230528 | RQ-00203078 98% | 250MG | $880 | 2026-05-27 | Buy |
| AK Scientific | 3074DH | CID49783953 | 10mg | $320 | 2021-12-16 | Buy |
| ApexBio Technology | B5872 | RQ-00203078 | 50mg | $275 | 2026-05-06 | Buy |
| ApexBio Technology | B5872 | RQ-00203078 | 10mg | $99 | 2026-05-06 | Buy |
| ApexBio Technology | B5872 | RQ-00203078 | 10mM(in 1mL DMSO) | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B5872 | RQ-00203078 | 10mM(in1mLDMSO) | $110 | 2026-05-06 | Buy |
| Arctom | HY-18662 | RQ-00203078 99.62% | 5mg | $53 | 2026-05-26 | Buy |
| Arctom | HY-18662 | RQ-00203078 99.62% | 10mM*1mLinDMSO(Solid+Solvent) | $61 | 2026-05-26 | Buy |
| Arctom | HY-18662 | RQ-00203078 99.62% | 10mM*1mLinDMSO(Solution) | $64 | 2026-05-26 | Buy |
Properties
Boiling point :602.0±65.0 °C(Predicted)
Density :1.588±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥27.25 mg/mL in EtOH
form :solid
pka :3.39±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
InChIKey :IJGQFZYYEHCCIZ-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(S(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC2=CC=C(OC(F)(F)F)C=C2)(=O)=O)C=C1
Density :1.588±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥27.25 mg/mL in EtOH
form :solid
pka :3.39±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
InChIKey :IJGQFZYYEHCCIZ-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(S(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC2=CC=C(OC(F)(F)F)C=C2)(=O)=O)C=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
RQ-00203078 is a selective antagonist of transient receptor potential melastatin 8 (TRPM8; IC50s = 8.3 and 5.8 nM in human and rat, respectively), while having little inhibitory action against TRPV1 (IC50 > 30 μM), TRPA1 (IC50 > 10 μM), TRPV4 (IC50 = 10 μM), or TRPM2 channels (IC50 > 10 μM). It attenuates icilin-induced wet-dog shakes in rats (ED50 = 0.65 mg/kg) after oral administration. RQ-00203078 has been shown to reduce HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. TRPM8, a member of the TRP melastatin subgroup, plays a role in cold hyperalgesia and cold allodynia caused by disease conditions such as chemotherapy-induced peripheral neuropathy, diabetic neuropathy, migraine, and overactive bladder. It is also known to be involved in the tumor progression of certain carcinomas.Related product price
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