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ChemicalBook >> CAS DataBase List >> SB216763

SB216763

$24 - $2060
Product name: SB216763
CAS: 280744-09-4
MF: C19H12Cl2N2O2
MW: 371.22
EINECS:
MDL Number:MFCD09753369
Synonyms:CS-332;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;SB 216763;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE;3-(2,4-Dichlorophenyl)-4-...;3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione;SB-216763(SB 216763);GSK-3 Inhibitor IV, SB-216763

Price94 Properties Safety Information Description

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Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
Ambeed
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
CSNpharm
DC Chemicals
Labseeker
Matrix Scientific
Sigma-Aldrich
SynQuest Laboratories
TCI Chemical
Tocris
TRC
Usbiological

Package

5.00mg
10mM*1mLinDMSO
50.00mg
2x50mg
500mg
10g
50
10.00mg
2x10mg
100.00mg
1
1mg
5mg
10mg
25mg
50mg
100mg
250mg
1g
5g
10mM*1mLinDMSO(Solid+Solvent)
10mM*1mLinDMSO(Solution)

Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%(HPLC)
Packaging5mg
Price$33
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging10mg
Price$47
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%(HPLC)
Packaging25mg
Price$55
Updated2026-05-28
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Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging50mg
Price$72
Updated2026-05-28
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Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging100mg
Price$87
Updated2026-05-28
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Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging250mg
Price$133
Updated2026-05-28
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Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging1mg
Price$24
Updated2026-05-28
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Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging1g
Price$396
Updated2026-05-28
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Manufactureraablocks
Product numberAA00BCHW
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging5g
Price$1564
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberC-2970
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging5G
Price$2060
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberC-2970
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging1G
Price$475
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberC-2970
Product description3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%
Packaging250MG
Price$180
Updated2026-05-27
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3659-M025
Product descriptionSB216763 ≥98%(HPLC)
Packaging25mg
Price$280
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3659-M001
Product descriptionSB216763 ≥98%(HPLC)
Packaging1mg
Price$30
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3659-M005
Product descriptionSB216763 ≥98%(HPLC)
Packaging5mg
Price$60
Updated2026-05-06
Buy

ManufacturerAmbeed
Product numberA100785
Product descriptionSB 216763 98%
Packaging10mg
Price$54
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%(HPLC)	5mg	$33	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	10mg	$47	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%(HPLC)	25mg	$55	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	50mg	$72	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	100mg	$87	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	250mg	$133	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	1mg	$24	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	1g	$396	2026-05-28	Buy
aablocks	AA00BCHW	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	5g	$1564	2026-05-28	Buy
ACHEMBLOCK	C-2970	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	5G	$2060	2026-05-27	Buy
ACHEMBLOCK	C-2970	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	1G	$475	2026-05-27	Buy
ACHEMBLOCK	C-2970	3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 98%	250MG	$180	2026-05-27	Buy
Adipogen Life Sciences	AG-CR1-3659-M025	SB216763 ≥98%(HPLC)	25mg	$280	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3659-M001	SB216763 ≥98%(HPLC)	1mg	$30	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3659-M005	SB216763 ≥98%(HPLC)	5mg	$60	2026-05-06	Buy
Ambeed	A100785	SB 216763 98%	10mg	$54	2021-12-16	Buy

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Properties

Melting point :287-288.6 °C(lit.)
Boiling point :598.1±50.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :Orange solid
pka :7.27±0.60(Predicted)
color :orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChIKey :JCSGFHVFHSKIJH-UHFFFAOYSA-N
SMILES :N1C(=O)C(C2C3=C(N(C)C=2)C=CC=C3)=C(C2=CC=C(Cl)C=C2Cl)C1=O

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning		P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.

Description

SB 216763 is a cell-permeable, potent, selective and ATP-competitive inhibitor of GSK-3 (Glycogen Synthase Kinase) with an IC₅₀ value of 34 nM for GSK-3α and with similar potency for GSK-3β. In PC-12 cells, SB-216763 exhibits neuroprotective properties and protects cultured central and peripheral nervous system neurones from cell death. Furthermore, SB-216763 increases the concentration of cytoplasmic β-catenin through a GSK-3 dependent manner. These inhibitory effects are similar to those of Wnt.

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Suppliers and manufacturers

Shanghai Jinyin Biological Technology Co., Ltd Shanghai Boyle Chemical Co., Ltd. 3B Pharmachem (Wuhan) International Co.,Ltd. Chembest Research Laboratories Limited Energy Chemical Ascent Scientific Jinan Trio PharmaTech Co., Ltd. China Langchem Inc. Dalian Meilun Biotech Co., Ltd. Shanghai civi chemical technology co.,Ltd

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SB216763

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