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ChemicalBook >> CAS DataBase List >> SU 9516

SU 9516

$15 - $1800
Product name: SU 9516
CAS: 377090-84-1
MF: C13H11N3O2
MW: 241.25
EINECS:
MDL Number:MFCD05865243
Synonyms:3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;CS-1784;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;SU 9516;SU-9516;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one

Price52 Properties Safety Information Description

52 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
Ambeed
ApexBio Technology
Arctom
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC
Usbiological

Package

1mg
5mg
10mg
25.00mg
25mg
50.00mg
50mg
100.00mg
100MG
10mM*1mLinDMSO(Solution)
250MG
500mg
1g
10mM*1mLinDMSO(Solid+Solvent)

Manufactureraablocks
Product numberAA00C6H3
Product description(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)
Packaging50mg
Price$91
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00C6H3
Product description(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)
Packaging25mg
Price$65
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00C6H3
Product description(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)
Packaging10mg
Price$38
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00C6H3
Product description(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)
Packaging5mg
Price$30
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00C6H3
Product description(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)
Packaging1mg
Price$15
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberX174330
Product description(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one 95%
Packaging100MG
Price$170
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberX174330
Product description(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one 95%
Packaging250MG
Price$340
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number2734AH
Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
Packaging25mg
Price$386
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2734AH
Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
Packaging5mg
Price$159
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2734AH
Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
Packaging1mg
Price$92
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging25mg
Price$98
Updated2021-12-16
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ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging50mg
Price$128
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging1mg
Price$29
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging5mg
Price$58
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging10mg
Price$75
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging100mg
Price$167
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00C6H3	(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)	50mg	$91	2026-05-28	Buy
aablocks	AA00C6H3	(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)	25mg	$65	2026-05-28	Buy
aablocks	AA00C6H3	(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)	10mg	$38	2026-05-28	Buy
aablocks	AA00C6H3	(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)	5mg	$30	2026-05-28	Buy
aablocks	AA00C6H3	(Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 99%(HPLC)	1mg	$15	2026-05-28	Buy
ACHEMBLOCK	X174330	(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one 95%	100MG	$170	2026-05-27	Buy
ACHEMBLOCK	X174330	(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one 95%	250MG	$340	2026-05-27	Buy
AK Scientific	2734AH	3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one	25mg	$386	2021-12-16	Buy
AK Scientific	2734AH	3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one	5mg	$159	2021-12-16	Buy
AK Scientific	2734AH	3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one	1mg	$92	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	25mg	$98	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	50mg	$128	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	1mg	$29	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	5mg	$58	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	10mg	$75	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	100mg	$167	2021-12-16	Buy

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Properties

Boiling point :601.521±55.00 °C(Press: 760.00 Torr)(predicted)
Density :1.383±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Store at +4°C
solubility :DMSO: ~17 mg/mL
form :crystalline
pka :12.195±0.10(predicted)
color :brown

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1). It does not inhibit PKC, p38, PDGFR, or EGFR (IC50’s = >10 μM). SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis. In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. 3B Pharmachem (Wuhan) International Co.,Ltd. VDM Biochemicals Haoyuan Chemexpress Co., Ltd. MedChemexpress LLC Nanjing Dulai Biotechnology Co., Ltd. Guangzhou Isun Pharmaceutical Co., Ltd CEG Chemical Science&Technology Co., Ltd. Bide Pharmatech Ltd. AdooQ Bioscience CHINA

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SU 9516

Properties

Safety Information

Description

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