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SU 9516

SU 9516 Structure
SU 9516 structure
CAS No.
377090-84-1
Chemical Name:
SU 9516
Synonyms
CS-1784;SU9516 ，S7636;SU 9516;SU-9516;SU 9516 USP/EP/BP;SU9516, 10 mM in DMSO;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one
CBNumber:
CB1497100
Molecular Formula:
C13H11N3O2
Molecular Weight:
241.25
MDL Number:
MFCD05865243
MOL File:
377090-84-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-28 08:09:22
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SU 9516 Properties

Boiling point 601.521±55.00 °C(Press: 760.00 Torr)(predicted)
Density 1.383±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at +4°C
solubility DMSO: ~17 mg/mL
form crystalline
pka 12.195±0.10(predicted)
color brown
FDA UNII FD2SWT2SDI

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3
NFPA 704
0
2 0

SU 9516 price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14796 SU 9516 ≥98% 377090-84-1 1mg $36 2026-04-30 Buy
Cayman Chemical 14796 SU 9516 ≥98% 377090-84-1 5mg $103 2026-04-30 Buy
Cayman Chemical 14796 SU 9516 ≥98% 377090-84-1 10mg $153 2026-04-30 Buy
Cayman Chemical 14796 SU 9516 ≥98% 377090-84-1 25mg $336 2026-04-30 Buy
Usbiological 256777 SU 9516 Asreported 377090-84-1 10mg $403 2026-06-03 Buy
Product number Packaging Price Buy
14796 1mg $36 Buy
14796 5mg $103 Buy
14796 10mg $153 Buy
14796 25mg $336 Buy
256777 10mg $403 Buy

SU 9516 Chemical Properties,Uses,Production

Uses

SU 9516 is a 3-substituted indolinone CDK inhibitor with potent and selective inhibition towards cyclin-dependant kinases.

Definition

ChEBI: 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one is a member of indoles.

Biological Activity

Potent, selective cdk2 inhibitor (IC 50 values are 0.022, 0.04, >10, >10, 18 and >100 μ M for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G 1 and G 2 -M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro .

IC 50

CDK2: 22 nM (IC50); CDK1: 40 nM (IC50); CDK4: 200 nM (IC50); PDGFr: 18000 nM (IC50)

References

[1]. lane me, yu b, rice a, et al. a novel cdk2-selective inhibitor, su9516, induces apoptosis in colon carcinoma cells. cancer res, 2001, 61(16): 6170-6177.
[2]. yu b, lane me, wadler s. su9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight e2f complexes in human colon carcinoma cells. biochem pharmacol, 2002, 64(7): 1091-1100.
[3]. gao n, kramer l, rahmani m, et al. the three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3h-imidazol-4-yl)-meth-(z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (su9516) kills human leukemia cells via down-regulation of mcl-1 through a transcriptional mechanism. mol pharmacol, 2006, 70(2): 645-655.

SU 9516 Preparation Products And Raw materials

Raw materials

Preparation Products

SU 9516 Suppliers

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
3B Pharmachem (Wuhan) International Co.,Ltd. 69
VDM Biochemicals 64
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Nanjing Dulai Biotechnology Co., Ltd. 55
Guangzhou Isun Pharmaceutical Co., Ltd 55
CEG Chemical Science&Technology Co., Ltd. 58
Bide Pharmatech Ltd. 60
AdooQ Bioscience CHINA 60

View Lastest Price from SU 9516 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SU9516 pictures 2026-07-27 SU9516
377090-84-1
 $30.00-105.00 99.96% 10g TargetMol Chemicals Inc.
3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one pictures 2019-12-24 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one
377090-84-1
 $1.00 1KG Min98% HPLC Career Henan Chemical Co
  • SU9516 pictures
  • SU9516
    377090-84-1
  • $30.00-105.00
  • 99.96%
  • TargetMol Chemicals Inc.

SU 9516 Spectrum

SU 9516(377090-84-1)1HNMR

377090-84-1(SU 9516)Related Search:

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3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one CS-1784 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one SU 9516;SU-9516 (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one (Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516 (3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one 2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)- SU 9516 USP/EP/BP Apoptosis,Autophagy,SU-9516,SU 9516,SU9516,inhibit,CDK,Cyclin dependent kinase,Inhibitor SU9516, 10 mM in DMSO SU9516 ，S7636 377090-84-1 Enzyme Inhibitors by Enzyme Intracellular Signaling Inhibitors A to Cyclin Dependant Kinase 2Serine/Threonine Kinase Biology Cyclin-Dependent Kinase (CDK)Cell Signaling and Neuroscience Kinase/Phosphatase Biology Protein Kinase Inhibitors Serine/Threonine Kinase Inhibitors