SirReal2
|
- $33 - $1900
- Product name: SirReal2
- CAS: 709002-46-0
- MF: C22H20N4OS2
- MW: 420.55
- EINECS:
- MDL Number:MFCD04173051
- Synonyms:SirReal2;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;SirReal2, 10 mM in DMSO
49 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2x5mg
- 1g
- 5 mg
- 10mM*1mLinDMSO(Solution)
- 50
- 10
- 25 mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- Manufactureraablocks
- Product numberAA01E50V
- Product descriptionSirReal2 ≥98%
- Packaging1mg
- Price$33
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E50V
- Product descriptionSirReal2 98+%
- Packaging5mg
- Price$55
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E50V
- Product descriptionSirReal2 98+%
- Packaging10mg
- Price$83
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E50V
- Product descriptionSirReal2 98+%
- Packaging25mg
- Price$113
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E50V
- Product descriptionSirReal2 98+%
- Packaging50mg
- Price$191
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E50V
- Product descriptionSirReal2 98+%
- Packaging100mg
- Price$322
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203319
- Product descriptionSirReal 2 98.00%
- Packaging100MG
- Price$635
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203319
- Product descriptionSirReal 2 98.00%
- Packaging250MG
- Price$1270
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4698CE
- Product description2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA197134
- Product descriptionSirReal2 98+%
- Packaging100mg
- Price$407
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA197134
- Product descriptionSirReal2 98+%
- Packaging50mg
- Price$241
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA197134
- Product descriptionSirReal2 98+%
- Packaging10mg
- Price$105
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA197134
- Product descriptionSirReal2 98+%
- Packaging25mg
- Price$142
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA197134
- Product descriptionSirReal2 98+%
- Packaging5mg
- Price$69
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA197134
- Product descriptionSirReal2 98+%
- Packaging250mg
- Price$691
- Updated2026-06-05
- Buy
- ManufacturerApexBio Technology
- Product numberB6016
- Product descriptionSirReal2
- Packaging100mg
- Price$679
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01E50V | SirReal2 ≥98% | 1mg | $33 | 2026-05-30 | Buy |
| aablocks | AA01E50V | SirReal2 98+% | 5mg | $55 | 2026-05-30 | Buy |
| aablocks | AA01E50V | SirReal2 98+% | 10mg | $83 | 2026-05-30 | Buy |
| aablocks | AA01E50V | SirReal2 98+% | 25mg | $113 | 2026-05-30 | Buy |
| aablocks | AA01E50V | SirReal2 98+% | 50mg | $191 | 2026-05-30 | Buy |
| aablocks | AA01E50V | SirReal2 98+% | 100mg | $322 | 2026-05-30 | Buy |
| ACHEMBLOCK | X203319 | SirReal 2 98.00% | 100MG | $635 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203319 | SirReal 2 98.00% | 250MG | $1270 | 2026-05-27 | Buy |
| AK Scientific | 4698CE | 2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide | 10mg | $336 | 2021-12-16 | Buy |
| Ambeed | A197134 | SirReal2 98+% | 100mg | $407 | 2026-06-05 | Buy |
| Ambeed | A197134 | SirReal2 98+% | 50mg | $241 | 2026-06-05 | Buy |
| Ambeed | A197134 | SirReal2 98+% | 10mg | $105 | 2026-06-05 | Buy |
| Ambeed | A197134 | SirReal2 98+% | 25mg | $142 | 2026-06-05 | Buy |
| Ambeed | A197134 | SirReal2 98+% | 5mg | $69 | 2026-06-05 | Buy |
| Ambeed | A197134 | SirReal2 98+% | 250mg | $691 | 2026-06-05 | Buy |
| ApexBio Technology | B6016 | SirReal2 | 100mg | $679 | 2026-05-06 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form :A crystalline solid
color :Off-white to light yellow
InChI :1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChIKey :MENNDDDTIIZDDN-UHFFFAOYSA-N
SMILES :CC1=NC(SCC(NC2=NC=C(S2)CC3=CC=CC4=C3C=CC=C4)=O)=NC(C)=C1
solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form :A crystalline solid
color :Off-white to light yellow
InChI :1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChIKey :MENNDDDTIIZDDN-UHFFFAOYSA-N
SMILES :CC1=NC(SCC(NC2=NC=C(S2)CC3=CC=CC4=C3C=CC=C4)=O)=NC(C)=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.Related product price
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2-Amino-4,6-dimethylpyrimidine
$5-1049 -
Acetamide
$6.35-1713.25 -
SirReal2
$33-1900
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