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ChemicalBook >> CAS DataBase List >> xav-939

xav-939

xav-939 price.
  • $7 - $3173
  • Product name: xav-939
  • CAS: 284028-89-3
  • MF: C14H11F3N2OS
  • MW: 312.31
  • EINECS:687-302-1
  • MDL Number:MFCD00106866
  • Synonyms:xav-939;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one;XAV 939/NVP-XAV939;CS-300;2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one;XAV 939, >=98%;SteMolecule;1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one
Price141 Properties Safety Information Description
141 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • Acints
  • Advanced Chemicals Intermediat
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 200mg
  • 10mM(1mLinDMSO)
  • 10mM(in1mLDMSO)
  • 500mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO
  • 10
  • 10mM*1mLinDMSO(Solution)
  • 2x25mg
  • EvaluationSample
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 5g
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
  • Packaging1mg
  • Price$18
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC)
  • Packaging5mg
  • Price$32
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
  • Packaging10mg
  • Price$42
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC)
  • Packaging25mg
  • Price$88
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
  • Packaging50mg
  • Price$125
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
  • Packaging100mg
  • Price$196
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039CE
  • Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
  • Packaging250mg
  • Price$359
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10254
  • Product descriptionXAV-939 98%
  • Packaging1G
  • Price$500
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10254
  • Product descriptionXAV-939 98%
  • Packaging100MG
  • Price$100
  • Updated2026-05-27
  • Buy
  • ManufacturerAcints
  • Product numberATI-06G-001
  • Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
  • Packaging250mg
  • Price$189
  • Updated2026-05-20
  • Buy
  • ManufacturerAcints
  • Product numberACI-02730
  • Product description2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+
  • Packaging1g
  • Price$498.15
  • Updated2026-05-20
  • Buy
  • ManufacturerAcints
  • Product numberATI-06G-001
  • Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
  • Packaging1g
  • Price$378
  • Updated2026-05-20
  • Buy
  • ManufacturerAcints
  • Product numberATI-06G-001
  • Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
  • Packaging5g
  • Price$918
  • Updated2026-05-20
  • Buy
  • ManufacturerAcints
  • Product numberACI-02730
  • Product description2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+
  • Packaging5g
  • Price$1510.65
  • Updated2026-05-20
  • Buy
  • ManufacturerAdvanced Chemicals Intermediat
  • Product numberATI-06G-001
  • Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
  • Packaging5g
  • Price$918
  • Updated2026-05-19
  • Buy
  • ManufacturerAdvanced Chemicals Intermediat
  • Product numberACI-02730
  • Product description2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+
  • Packaging5g
  • Price$1510.65
  • Updated2026-05-19
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% 1mg $18 2026-05-28 Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC) 5mg $32 2026-05-28 Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% 10mg $42 2026-05-28 Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC) 25mg $88 2026-05-28 Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% 50mg $125 2026-05-28 Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% 100mg $196 2026-05-28 Buy
aablocks AA0039CE 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% 250mg $359 2026-05-28 Buy
ACHEMBLOCK 10254 XAV-939 98% 1G $500 2026-05-27 Buy
ACHEMBLOCK 10254 XAV-939 98% 100MG $100 2026-05-27 Buy
Acints ATI-06G-001 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable 250mg $189 2026-05-20 Buy
Acints ACI-02730 2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+ 1g $498.15 2026-05-20 Buy
Acints ATI-06G-001 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable 1g $378 2026-05-20 Buy
Acints ATI-06G-001 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable 5g $918 2026-05-20 Buy
Acints ACI-02730 2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+ 5g $1510.65 2026-05-20 Buy
Advanced Chemicals Intermediat ATI-06G-001 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable 5g $918 2026-05-19 Buy
Advanced Chemicals Intermediat ACI-02730 2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+ 5g $1510.65 2026-05-19 Buy
Next Last

Properties

Boiling point :429.3±55.0 °C(Predicted)
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI :1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChIKey :KLGQSVMIPOVQAX-UHFFFAOYSA-N
SMILES :FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. It is regulated through degradation of the downstream effector β-catenin via a complex consisting of the tumor suppressor APC, axin, and glycogen synthase kinase 3 (GSK3). Axin is the concentration-limiting factor for this degradation complex. Initially indentified as telomere-associated proteins, tankyrases promote axin ubiquitination, possibly through poly-ADP-ribosylation (PARsylation). XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 with IC50 values of 11 and 4 nM, respectively. By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.33 μM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
XAV-939
$48.00
XAV-939 CAS:284028-89-3
ATK CHEMICAL COMPANY LIMITED
Biochempartner
CONIER CHEM AND PHARMA LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Dideu Industries Group Limited
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nanjing Doge Biomedical Technology Co., Ltd