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| | 4-tert-Butylcyclohexanol Basic information |
| Product Name: | 4-tert-Butylcyclohexanol | | Synonyms: | 4-tert-butylcyclohexanol,mixtureofisomers;Cyclohexanol, 4-tert-butyl-;Padaryl;USAF do-20;usafdo-20;4-Tert-Butylcyclohexanol (Cis- And Trans- Mixture);P-TERTIARY BUTYL CYCLO HEXANOL;4-#ntert.-Butylcyclohexanol | | CAS: | 98-52-2 | | MF: | C10H20O | | MW: | 156.27 | | EINECS: | 202-676-4 | | Product Categories: | Alcohols;C9 to C30;Oxygen Compounds | | Mol File: | 98-52-2.mol |  |
| | 4-tert-Butylcyclohexanol Chemical Properties |
| Melting point | 62-70 °C(lit.) | | Boiling point | 110-115 °C15 mm Hg(lit.) | | density | 2.591 | | vapor pressure | 6-201.38Pa at 25-65℃ | | refractive index | 1.447 | | Fp | 221 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | Powder or Granules | | pka | 15.32±0.40(Predicted) | | color | White | | Odor | at 100.00 %. woody musty patchouli camphor mint leather | | Odor Type | woody | | Water Solubility | <1 g/L (20 ºC) | | BRN | 1902277 | | InChIKey | CCOQPGVQAWPUPE-UHFFFAOYSA-N | | LogP | 3.23 at 20℃ | | CAS DataBase Reference | 98-52-2(CAS DataBase Reference) | | NIST Chemistry Reference | Cyclohexanol, 4-(1,1-dimethylethyl)-(98-52-2) | | EPA Substance Registry System | Cyclohexanol, 4-(1,1-dimethylethyl)- (98-52-2) |
| Risk Statements | 23/25-33-50/53 | | Safety Statements | 24/25-61-60-45-28-20/21 | | RIDADR | 3256 | | WGK Germany | 1 | | RTECS | GV8750000 | | HS Code | 29061900 | | toxicity | The acute oral LD50 in rats was reported as 4-2 g/kg (3-62-4-87 g/kg)(Denine, 1973). The acute dermal LD50 in rabbits was reported as > 5 g/kg (Denine, 1973). |
| | 4-tert-Butylcyclohexanol Usage And Synthesis |
| Chemical Properties | It is white needle-shaped or powdery crystals with a woody, patchouli-like aroma. | | Occurrence | Has apparently not been reported to occur in nature. | | Uses | 4-tert-Butylcyclohexanol (mixture of cis and trans) can be used as a reactant to synthesize tris(4,4′-di-tert-butyl-2,2′-bipyridine)(trans-4-tert-butylcyclohexanolato)deca-μ-oxido-heptaoxidoheptavanadium oxide cluster complex by reacting with [V8O20(C18H24N2)4]. It can also be used as a reactant in competitive Oppenauer oxidation experiments in the presence of zeolite BEA as a stereoselective catalyst. Only cis-isomer is selectively converted to the corresponding ketone, whereas trans-isomer remains unchanged. | | Preparation | From 4-terf-butylphenol by hydrogenation(Arctander, 1969). | | Synthesis Reference(s) | The Journal of Organic Chemistry, 45, p. 2724, 1980 DOI: 10.1021/jo01301a040
Synthesis, p. 171, 1977 DOI: 10.1055/s-1977-24307 | | General Description | 4-tert-Butylcyclohexanol is a soothing molecule whose special feature is to instantly decrease stinging and burning sensations. According to the manufacturer's impressive numbers, it can reduce stinging up to 78% and burning sensation by up to 80% after just 3 minutes.
It is so effective because it works at a cellular level via intercepting the signals caused by the irritation before they can reach the neuro-receptor. This means that we feel stinging and burning sensations much less and the skin's tolerance threshold is increased.
The effectiveness of SymSitive was also backed up by a comparative study. It found that both 4‐t‐Butylcyclohexanol and fellow cell-communicating, soothing molecule acetyl dipeptide‐1 cetyl ester works, but 4‐t‐Butylcyclohexanol works better. | | Synthesis | Phenol and isobutylene carry out tert-butylation reaction in the presence of aluminum trichloride, and catalytic hydrogenation with Rays Nickel W7, two kinds of geometric structures can be obtained, in which the trans structure accounts for more than 70%. | | References | [1] Patent: US6388149, 2002, B2. Location in patent: Page column 17
[2] Patent: US6388149, 2002, B2. Location in patent: Page column 17
[3] RSC Advances, 2014, vol. 4, # 6, p. 2729 - 2732
[4] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1911, vol. 152, p. 609
[5] Journal of applied chemistry of the USSR, 1984, vol. 57, # 10 pt 2, p. 2138 - 2142 |
| | 4-tert-Butylcyclohexanol Preparation Products And Raw materials |
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