3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- manufacturers
- A-933548
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- $2180.00
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2026-04-21
- CAS:1037826-43-9
- Purity:
- Supply Ability: 10g
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| | 3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- Basic information |
| | 3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- Chemical Properties |
| density | 1.31±0.1 g/cm3(Predicted) | | pka | 11.92±0.46(Predicted) |
| | 3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- Usage And Synthesis |
| Description | A-933548 is a potent Calpain inhibitor for the Treatment of Alzheimer's Disease. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays | | Uses | A-933548 is a potent and selective inhibitor of calpain, with a Ki of 18 nM. A-933548 can be used for the research of Alzheimer's disease[1]. | | References | [1] Kling A, et, al. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem. 2017 Aug 24;60(16):7123-7138. DOI:10.1021/acs.jmedchem.7b00731 |
| | 3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- Preparation Products And Raw materials |
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