3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]-

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3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- manufacturers

  • A-953227
  • A-953227 pictures
  • $2800.00
  • 2026-04-20
  • CAS:1037826-77-9
  • Purity:
  • Supply Ability: 10g
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Basic information
Product Name:3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]-
Synonyms:3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]-;A 953227;A953227;A-953227
CAS:1037826-77-9
MF:C25H20FN5O3
MW:457.46
EINECS:
Product Categories:
Mol File:1037826-77-9.mol
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Structure
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Chemical Properties
density 1.35±0.1 g/cm3(Predicted)
pka11.91±0.46(Predicted)
Safety Information
MSDS Information
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Usage And Synthesis
UsesA-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain). A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease[1].
References[1] Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Preparation Products And Raw materials
Tag:3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]-(1037826-77-9) Related Product Information
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- NA 3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-[3-(4-fluorophenyl)-1H-pyrazol-1-yl]- Urokinase Tosyl-L-Phenylalanine chloromethylketone Trypsin