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| | 6-Monodeoxy-6-monoamino-beta-cyclodextrine Basic information |
| Product Name: | 6-Monodeoxy-6-monoamino-beta-cyclodextrine | | Synonyms: | 6(I)-amino-6(I)-deoxycyclomaltoheptaose;6-Monodeoxy-6-monoamino-beta-cyclodextrine;Mono-6-Amino-6-deoxy-beta-Cyclodextrin;6-AMino-6-deoxy -cyclodextrin;mono-6-amino-mono-6-deoxy-β-CD;Mono-(6-amino-6-deoxy)-β-cyclodextrin;Mono-(6-amino-6-deoxy)-2-cyclodextrin;6-Monodeoxy-6-MonoaMino-β-cyclodextrine | | CAS: | 29390-67-8 | | MF: | C42H71NO34 | | MW: | 1134 | | EINECS: | 1312995-182-4 | | Product Categories: | Cyclodextrins | | Mol File: | 29390-67-8.mol |  |
| | 6-Monodeoxy-6-monoamino-beta-cyclodextrine Chemical Properties |
| Melting point | 203 °C (decomp) | | Boiling point | 1527.8±60.0 °C(Predicted) | | density | 1.608±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Soluble in water, DMF, DMSO.Insoluble in acetone, methanol, chloroform. | | form | Solid powder or crystals | | pka | 12.57±0.70(Predicted) | | color | White to off-white | | Stability: | Hygroscopic | | CAS DataBase Reference | 29390-67-8 |
| | 6-Monodeoxy-6-monoamino-beta-cyclodextrine Usage And Synthesis |
| Chemical Properties | suitable for coupling to carboxyl- or aldehyde-containing ligands | | Uses | suitable for coupling to carboxyl- or aldehyde-containing ligands | | Uses | 6-Monoamino-β-cyclodextrin is synthesized as fluorescent sensor of moleclular recognition. | | Synthesis | Synthesis of mono-(6-amino-6-deoxy)-β-cyclodextrin (CDNH2): 30 mL of an aqueous ammonia solution was added to 3 g of crude mono-6-O-(p-toluenesulfonyl)-β-cyclodextrin (CDOT) and the reaction mixture was stirred for 72 h at 50 °C. The reaction was carried out in a cold acetone solution. Upon completion of the reaction, the solution was recrystallized in cold acetone to give the crude product CDNH2. This crude product was subsequently purified by a cation exchange column, sequentially using deionized water and 0.1 M (NH4)2CO3 buffered aqueous solution as eluents. The total yield of the purified product was 79%. The reaction process and product purity were monitored by thin-layer chromatography (TLC) with the unfolding agent ratio of 1-propanol:ethyl acetate:water:NH3-H2O = 3:1:2:1 (v/v) and color development using CAM solution. | | References | [1] Tetrahedron Letters, 2010, vol. 51, # 5, p. 800 - 803
[2] Patent: WO2016/126910, 2016, A1. Location in patent: Page/Page column 29
[3] Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2012, vol. 73, # 1-4, p. 475 - 478
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 11, p. 3346 - 3348
[5] Angewandte Chemie - International Edition, 2015, vol. 54, # 41, p. 12127 - 12133 |
| | 6-Monodeoxy-6-monoamino-beta-cyclodextrine Preparation Products And Raw materials |
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