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| | 5-(2-Bromophenyl)-1H-tetrazole Basic information | | Uses |
| | 5-(2-Bromophenyl)-1H-tetrazole Chemical Properties |
| Melting point | 182-184 °C(lit.) | | Boiling point | 389.3±44.0 °C(Predicted) | | density | 1.8047 (rough estimate) | | refractive index | 1.6700 (estimate) | | storage temp. | Sealed in dry,2-8°C | | pka | 3.78±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | BRN | 148567 | | InChI | 1S/C7H5BrN4/c8-6-4-2-1-3-5(6)7-9-11-12-10-7/h1-4H,(H,9,10,11,12) | | InChIKey | YHVBXKTXLJTDRI-UHFFFAOYSA-N | | SMILES | Brc1ccccc1-c2nnn[nH]2 | | CAS DataBase Reference | 73096-42-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37 | | WGK Germany | 3 | | HS Code | 29339990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-(2-Bromophenyl)-1H-tetrazole Usage And Synthesis |
| Uses | 5-(2-BROMOPHENYL)-1H-TETRAZOLE is a heterocyclic organic compound that can be used as an extremely important intermediate in organic synthesis. It can be used to synthesize pharmaceutical, pesticide, and industrial foaming agent products. | | Chemical Properties | white to off-white powder | | Uses | 5-(2-Bromophenyl)-1H-tetrazole is a 5-substituted 1H-tetrazole. It can be synthesized via silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide. Copper-catalyzed reaction of 5-(2-bromophenyl)-1H-tetrazole with ethyl 2-cyanoacetate has been reported to afford ethyl 1,3-diaminoisoquinoline-4-carboxylate. | | General Description | 5-(2-Bromophenyl)-1H-tetrazole is a 5-substituted 1H-tetrazole. It can be synthesized via silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide. Copper-catalyzed reaction of 5-(2-bromophenyl)-1H-tetrazole with ethyl 2-cyanoacetate has been reported to afford ethyl 1,3-diaminoisoquinoline-4-carboxylate. | | Synthesis | Step 2) Synthesis of 5-(2-bromophenyl)-1H-tetrazole: A mixture of 2-bromobenzonitrile (10.0 g, 0.055 mol), sodium azide (3.9 g, 0.060 mol), ammonium chloride (3.2 g, 0.060 mol), and N,N-dimethylformamide (DMF, 90 mL) was heated for 18 hours at 100 °C. After completion of the reaction, the mixture was concentrated, dissolved in water and adjusted to alkaline (pH 9) with 1N potassium hydroxide (KOH) solution. The aqueous phase was extracted with ether (the organic phase was discarded) and subsequently acidified with 2N hydrochloric acid (HCl). The precipitate precipitated was collected by filtration to afford 9.1 g (73% yield) of the target product, 5-(2-bromophenyl)-1H-tetrazole, as an off-white solid with melting point 179-181 °C. The 1H NMR (DMSO-d6) data were as follows: δ 7.56 (m, 2H), 7.69 (dd, J = 7.0 Hz, 2.1 Hz, 1H), 7.86 (dd, J = 7.6 Hz, 1.3 Hz, 1H). | | References | [1] Patent: WO2017/59411, 2017, A1. Location in patent: Paragraph 00386
[2] Patent: WO2006/81807, 2006, A2. Location in patent: Page/Page column 20; 33-34
[3] Patent: EP838458, 1998, A1
[4] Research on Chemical Intermediates, 2017, vol. 43, # 12, p. 7365 - 7374
[5] Tetrahedron Letters, 2014, vol. 55, # 24, p. 3507 - 3510 |
| | 5-(2-Bromophenyl)-1H-tetrazole Preparation Products And Raw materials |
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