1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)-

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1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- Suppliers list
Company Name: Shandong Dayou Pharmaceutical Research and Development Co., Ltd.  
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Email: hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.com

1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- manufacturers
1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- Basic information
Product Name:1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)-
Synonyms:1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)-;JNK3 inhibitor-4
CAS:2409109-65-3
MF:C28H27N7O
MW:477.56
EINECS:
Product Categories:
Mol File:2409109-65-3.mol
1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- Structure
1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- Chemical Properties
Boiling point 814.7±75.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka2.31±0.10(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- Usage And Synthesis
UsesJNK3 inhibitor-4 is a potent inhibitor of JNK3 (IC50=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC50=143.9 nM) and JNK2 (IC50=298.2 nM)[1]. JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability[1].
in vivo

JNK3 inhibitor-4 improves memory for the Alzheimer’s disease mouse model. JNK3 inhibitor-4 (compound 15d) (10 or 30 mg/kg; i.v.; 3 times/week for 1 month in 9-month-old APP/PS1 3Tx3Tg mice) results significantly higher spontaneous alteration and response latency of mouse (at 27th or 30th days) compared to the APP/PS1vehicle groups in Y-maze test and passive avoidance test, with a dose correlation[1].
JNK3 inhibitor-4 (30 mg/kg; p.o.; single dose) shows blood-brain barrier permeability with brain to plasma ratio of 0.02 in SD rats[1].
Pharmacokinetics in rats[1]

RouteDose (mg/kg)AUC0-t (ng·h/mL)Cmax (ng/mL)Tmax (h)T1/2 (h)BA (%)
IV1718.00.22
PO3337.5377.820.630.3415.67
IC 50JNK3: 1.0 nM (IC50); JNK1: 143.9 nM (IC50); JNK2: 298.2 nM (IC50)
References[1] Jun J, et al. Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894. DOI:10.1016/j.ejmech.2022.114894
1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- Preparation Products And Raw materials
Tag:1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)-(2409109-65-3) Related Product Information
1H-Imidazole-5-acetonitrile, 1-[2-[[(3S)-1-(cyclopropylcarbonyl)-3-piperidinyl]amino]-4-pyrimidinyl]-2-(2-naphthalenyl)- JNK3 inhibitor-3 3-[2-[[(3S)-1-(cyclopropanecarbonyl)piperidin-3-yl]amino]pyrimidin-4-yl]-2-(3,4-dichlorophenyl)-5,6-dihydro-4H-cyclopenta[d]imidazole-5-carboxamide gamma-Glu-Cys trifluoroacetate salt p- Cresol sulfate ammonium salt H-Yc dehfc gamma-OH, cyclic