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| | 2-Pyridinecarbonitrile,6-(1-methylethyl)-(9CI) Basic information |
| Product Name: | 2-Pyridinecarbonitrile,6-(1-methylethyl)-(9CI) | | Synonyms: | 2-Pyridinecarbonitrile,6-(1-methylethyl)-(9CI);2-Cyano-6-isopropylpyridine;6-(propan-2-yl)pyridine-2-carbonitrile;6-Isopropylpicolinonitrile;6-(1-methylethyl)-2-Pyridinecarbonitrile;6-Isopropylpyridine-2-carbonitrile;2-Pyridinecarbonitrile, 6-(1-methylethyl)- | | CAS: | 337904-76-4 | | MF: | C9H10N2 | | MW: | 146.19 | | EINECS: | | | Product Categories: | PYRIDINE | | Mol File: | 337904-76-4.mol |  |
| | 2-Pyridinecarbonitrile,6-(1-methylethyl)-(9CI) Chemical Properties |
| Boiling point | 226.6±28.0 °C(Predicted) | | density | 1.02±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 0.29±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 2-Pyridinecarbonitrile,6-(1-methylethyl)-(9CI) Usage And Synthesis |
| Synthesis | 1B: General procedure for the synthesis of 2-cyano-6-isopropylpyridine (105). A mixture of 2-isopropylpyridine-N-oxide (104, 1.33 g, 9.7 mmol) with trimethylcyanosilane (TMS-CN, 1.42 mL, 1.06 g, 11.0 mmol) in 1,2-dichloroethane (40 mL) was stirred at room temperature for 5 min. Subsequently, diethylcarbamoyl chloride (Et2NCOCl, 1.23 mL, 9.7 mmol) was added and stirring was continued at room temperature under inert atmosphere. After 2 days of reaction, 10% aqueous potassium carbonate solution was added and stirring was continued for 10 min. The organic layer was separated and the aqueous layer was extracted twice with 1,2-dichloroethane. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 3:1) to afford 6-isopropylpyridinecarbonitrile 1.06 g (74% yield): m/z = 147 (M + H)+. | | References | [1] Patent: WO2007/14926, 2007, A1. Location in patent: Page/Page column 108
[2] European Journal of Inorganic Chemistry, 2006, # 2, p. 366 - 379
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 5, p. 453 - 458 |
| | 2-Pyridinecarbonitrile,6-(1-methylethyl)-(9CI) Preparation Products And Raw materials |
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