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| | tetrahydroharmine Basic information |
| Product Name: | tetrahydroharmine | | Synonyms: | tetrahydroharmine;Tetrahydroharmin;1,2,3,4-Tetrahydroharmine;1H-Pyrido(3,4-B)indole, 2,3,4,9-tetrahydro-7-methoxy-1-methyl- (van);7-methoxy-1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole;HARMALINE-001;2,3,4,9-tetrahydro-7-methoxy-1-methyl-1H-Pyrido[3,4-b]indole;1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-7-methoxy-1-methyl- | | CAS: | 17019-01-1 | | MF: | C13H16N2O | | MW: | 216.28 | | EINECS: | | | Product Categories: | | | Mol File: | 17019-01-1.mol |  |
| | tetrahydroharmine Chemical Properties |
| Melting point | 199 °C | | Boiling point | 399.2±37.0 °C(Predicted) | | density | 1.145±0.06 g/cm3(Predicted) | | storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 18.03±0.40(Predicted) | | color | White to Off-White | | Stability: | Light Sensitive |
| WGK Germany | WGK 2 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | tetrahydroharmine Usage And Synthesis |
| Description | This carboline alkaloid is present in Banisteria caapi, a plant indigenous toSouth America. It is dextrorotatory with [o:]l>s + 32° (c 1.0, CHCI3). One
methoxyl group, a methyl group and two imino groups are present in the
molecule. | | Uses | Tetrahydroharmine is a β-Carboline derivative. β-Carboline alkaloids are inhibitors of human monoamine oxidase enzymes. β-carboline derivatives were also reported to have antiviral and fungicidal activity. Tetrahydroharmine is related to 3,4-Dihydroharmine (D449718). | | IC 50 | MAO-B: 74 nM (IC50) | | References | Hochstein, Paradies., J. Arner. Chern. Soc., 79, 5735 (1957)
Bernauer., Helv. Chirn. Acta, 47, 1075 (1960)
Koblicova, Trojanek., Chern. Ind., 1342 (1966) |
| | tetrahydroharmine Preparation Products And Raw materials |
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