fumitremorgin B

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fumitremorgin B Basic information
Product Name:fumitremorgin B
Synonyms:fumitremorgin B;FUMITREMORGENB;(5aR)-1,2,3,5a,6,11,12,14aβ-Octahydro-5aβ,6β-dihydroxy-9-methoxy-11-(3-methyl-2-butenyl)-12α-(2-methyl-1-propenyl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione;Lanosulin;5H,14H-Pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione, 1,2,3,5a,6,11,12,14a-octahydro-5a,6-dihydroxy-9-methoxy-11-(3-methyl-2-buten-1-yl)-12-(2-methyl-1-propen-1-yl)-, (5aR,6S,12S,14aS)-;B Fumitremorgin B;Fumitremorgin
CAS:12626-17-4
MF:C27H33N3O5
MW:479.57
EINECS:
Product Categories:
Mol File:12626-17-4.mol
fumitremorgin B Structure
fumitremorgin B Chemical Properties
Melting point 205-207 °C
Boiling point 724.3±60.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: Soluble,Methanol: Soluble
form A solid
pka10.74±0.60(Predicted)
Safety Information
MSDS Information
fumitremorgin B Usage And Synthesis
DescriptionThis tremorgenic alkaloid is highly toxic and is elaborated by Aspergillus jurnigatus. The structure given above has been determined from X-ray crystallography. The crystals are orthorhombic with space group P2 1212 1, a = 14.771, b = 24.925 and c = 7.321 A with Z = 4. The absolute configuration is based upon that of L( - )-proline formed by acid hydrolysis of the alkaloid.
UsesFumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL[1][2][3].
DefinitionChEBI: An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi via a tryptophan-proline diketopiperazine intermediate.
ReferencesYamazaki et al., Tetrahedron Lett., 27 (1975)
fumitremorgin B Preparation Products And Raw materials
Tag:fumitremorgin B(12626-17-4) Related Product Information
Fumitremorgin A tetrahydroharmine (1,4-Dimethyl-2-piperazinyl)methanol 5-(DIISOPROPYLAMINO)AMYLAMINE (S)-1-ISOPROPYL-2-METHYL-PIPERAZINE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE 6-Methoxytrytophol 1-(1H-INDOL-3-YL)-ETHANOL 1-ISOPROPYL-PIPERAZIN-2-ONE CYCLO(-GLY-TRP) 2-amino-1-(1H-indol-3-yl)ethanol CYCLO(-ALA-SER) CYCLO(-GLY-SER) fumitremorgin B Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 3-Pyrrolidino-1,2-propanediol Cyclo(-Gly-Pro) 1-Isopropyl-2-methyl-piperazine