quinidine polygalacturonate manufacturers
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| | quinidine polygalacturonate Basic information |
| Product Name: | quinidine polygalacturonate | | Synonyms: | D-Galacturonic acid, homopolymer, compd. with (9S)-6'-methoxycinchonan-9-ol;Naticardina;Qalactoquin;Quinilac;Ritmocor;Sineflutter;D-Galacturonic acid, homopolymer, compd. with (9S)-6′-methoxycinchonan-9-ol (9CI, ACI) | | CAS: | 27555-34-6 | | MF: | C26H34N2O9 | | MW: | 518.55616 | | EINECS: | | | Product Categories: | Polymers | | Mol File: | 27555-34-6.mol |  |
| | quinidine polygalacturonate Chemical Properties |
| RIDADR | 1544 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | quinidine polygalacturonate Usage And Synthesis |
| Uses | Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research[1][2][3][4]. | | in vivo | Quinidine polygalacturonate shows effects on the PTZ-induced seizure threshold[5]. | Animal Model: | Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5] | | Dosage: | 10, 20, and 30 mg/kg | | Administration: | Intraperitoneal injection; 10, 20, and 30 mg/kg; once | | Result: | Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05). |
| | IC 50 | Plasmodium | | References | [1] Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13. DOI:10.1111/j.1476-5381.1991.tb09867.x
[2] Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. Pharmacol Ther. 1983;23(2):179-91. DOI:10.1016/0163-7258(83)90012-8
[3] Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7. DOI:10.1093/jat/14.5.311
[4] Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31. DOI:10.1002/tox.20568
[5] Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988. DOI:10.1016/j.neulet.2020.134988 |
| | quinidine polygalacturonate Preparation Products And Raw materials |
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