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| | Thalidomide-4-NH-C10-COO(t-Bu) Basic information |
| Product Name: | Thalidomide-4-NH-C10-COO(t-Bu) | | Synonyms: | Thalidomide-4-NH-C10-COO(t-Bu);2-(2,6-Dioxohexahydropyridin-3-yl)-4-(undecylamino)isoindole-1,3-dione;Thalidomide-NH-C10-Boc;tert-butyl 11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propanoate | | CAS: | 2428400-25-1 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Thalidomide-4-NH-C10-COO(t-Bu) Structure]() |
| | Thalidomide-4-NH-C10-COO(t-Bu) Chemical Properties |
| | Thalidomide-4-NH-C10-COO(t-Bu) Usage And Synthesis |
| Uses | Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958)[1]. | | References | [1] Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity |
| | Thalidomide-4-NH-C10-COO(t-Bu) Preparation Products And Raw materials |
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