Pomalidomide-PEG3-N3 manufacturers
|
| | Pomalidomide-PEG3-N3 Basic information |
| Product Name: | Pomalidomide-PEG3-N3 | | Synonyms: | Pomalidomide-PEG3-N3;Pomalidomide-NH-CO-PEG3-N3;2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader;N3-PEG3-CH2CO-Poma;Acetamide, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG3-azide;2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide;2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide | | CAS: | 2267306-15-8 | | MF: | C21H24N6O8 | | MW: | 488.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2267306-15-8.mol |  |
| | Pomalidomide-PEG3-N3 Chemical Properties |
| Melting point | 165 °C | | storage temp. | 2-8°C | | solubility | DMSO: 200 mg/mL (409.46 mM) | | form | Solid | | color | White to yellow | | InChIKey | DUTLUBRCOXPZLI-UHFFFAOYSA-N | | SMILES | O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN=[N+]=[N-])=O)=O)NC1=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Pomalidomide-PEG3-N3 Usage And Synthesis |
| Uses | Protein degrader builiding block Pomalidomide-PEG3-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. | | reaction suitability | reaction type: click chemistry
reagent type: ligand-linker conjugate | | IC 50 | Cereblon |
| | Pomalidomide-PEG3-N3 Preparation Products And Raw materials |
|