NLRP3-IN-21 manufacturers
- NLRP3-IN-21
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- $2500.00
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2026-05-11
- CAS:2956791-61-8
- Purity:
- Supply Ability: 10g
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| | NLRP3-IN-21 Basic information |
| Product Name: | NLRP3-IN-21 | | Synonyms: | NLRP3-IN-21;Thieno[2′,3′:4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-one, 2-chloro-7-[[5-[2-chloro-6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl]methyl]-5-(1-methylethyl)- | | CAS: | 2956791-61-8 | | MF: | C20H13Cl2F3N6O2S | | MW: | 529.32 | | EINECS: | | | Product Categories: | | | Mol File: | 2956791-61-8.mol |  |
| | NLRP3-IN-21 Chemical Properties |
| Boiling point | 634.781±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.757±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | -1.888±0.12(predicted) | | form | Solid | | color | White to off-white |
| | NLRP3-IN-21 Usage And Synthesis |
| Uses | NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly[1]. | | References | [1] Na Li, et al. Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis. J Med Chem. 2023 Oct 12;66(19):13428-13451. DOI:10.1021/acs.jmedchem.3c00696 |
| | NLRP3-IN-21 Preparation Products And Raw materials |
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