- 6-CHLOROTHYMINE
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- $0.00 / 25kg
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2025-12-24
- CAS:1627-28-7
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- 6-CHLOROTHYMINE
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- $1.10 / 1g
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2025-11-18
- CAS:1627-28-7
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 6-CHLOROTHYMINE
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- $5.00 / 1KG
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2019-09-11
- CAS:1627-28-7
- Min. Order: 1KG
- Purity: 85.0-99.9%
- Supply Ability: 100g,1kg,5kg
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| | 6-CHLOROTHYMINE Basic information |
| Product Name: | 6-CHLOROTHYMINE | | Synonyms: | 6-CHLOROTHYMINE;6-Chloro-5-methylpyrimidine-2,4(1H,3H)-dione;6-CHLORO-5-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE;6-Chloro-5-Methyl-1H-pyriMidine-2,4-dione;6-Chloro-5-Methyluracil;EOS-62068;2,4(1H,3H)-Pyrimidinedione, 6-chloro-5-methyl-;6-CHLOROTHYMINE ISO 9001：2015 REACH | | CAS: | 1627-28-7 | | MF: | C5H5ClN2O2 | | MW: | 160.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1627-28-7.mol |  |
| | 6-CHLOROTHYMINE Chemical Properties |
| Melting point | 266-267 °C(Solv: water (7732-18-5)) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 6.52±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 6-CHLOROTHYMINE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 6-chloro-5-methylpyrimidine-2,4(1H,3H)-dione from 5-methylbarbituric acid (CAS:2417-22-3) was as follows: under nitrogen protection, 5-methylbarbituric acid (9.40 g, 0.066 mol) and benzyltriethylammonium chloride (BTAC) (30.14 g, 0.13 mol) were suspended in trichloro phosphorus oxide (POCl3) (154 mL, 1.65 mol) and heated at 50 °C with stirring for 7 hours. Upon completion of the reaction, the mixture was cooled to room temperature and evaporated to dryness under vacuum. The residue was carefully quenched with 285 g of ice water at 0 °C and the slurry was subsequently placed in a refrigerator overnight. The precipitate was collected by filtration, washed with cold water and dried under vacuum in the presence of phosphorus pentoxide to give 6-chloro-5-methylpyrimidine-2,4(1H,3H)-dione (5.60 g, 0.035 mol, 53% yield) as a white solid. The melting point of the product was 270-272 °C. 1H NMR (300 MHz, DMSO-d6) δ (ppm): 11.81 (br s, 1H, NH), 11.32 (br s, 1H, NH), 1.82 (s, 3H, CH3). IR (KBr, ν cm-1): 3158 (NH), 3013,2814 (Csp2-H ), 1711,1647 (C=O), 1625 (C=C), 1491 (NH), 1424 (C-N), 891 (NH), 753 (C-Cl). | | References | [1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 159 - 174 |
| | 6-CHLOROTHYMINE Preparation Products And Raw materials |
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