PROTAC BTK Degrader-6

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PROTAC BTK Degrader-6 Basic information
Product Name:PROTAC BTK Degrader-6
Synonyms:PROTAC BTK Degrader-6;1H-Isoindole-1,3(2H)-dione, 5-[3-[[4-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-oxoethyl]-1-piperazinyl]methyl]-1-azetidinyl]-2-(2,6-dioxo-3-piperidinyl)-
CAS:2767204-39-5
MF:C45H47N11O6
MW:837.93
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Product Categories:
Mol File:2767204-39-5.mol
PROTAC BTK Degrader-6 Structure
PROTAC BTK Degrader-6 Chemical Properties
density 1.545±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka10.832±0.40(predicted)
Safety Information
MSDS Information
PROTAC BTK Degrader-6 Usage And Synthesis
UsesPROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6)[1].
References[1] Huang J, et al. Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation. Eur J Med Chem. 2023 Jul 18;259:115664. DOI:10.1016/j.ejmech.2023.115664
PROTAC BTK Degrader-6 Preparation Products And Raw materials
Tag:PROTAC BTK Degrader-6(2767204-39-5) Related Product Information
PROTAC BTK Degrader-6 (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one 1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- GBD-9 Ibrutinib Dimer Impurity Ibrutinib Impurity 15