1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)-
CAS:2563861-90-3
MF:C41H40N10O5
MW:752.82
EINECS:
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Mol File:2563861-90-3.mol
1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
density 1.59±0.1 g/cm3(Predicted)
pka10.83±0.40(Predicted)
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
UsesPROTAC BTK Degrader-3 is a potent BTK degrader with a DC50 value of 10.9 nM of BTK degradation in Mino cells. PROTAC BTK Degrader-3 has the potential forB-cell malignancies, including chronic lymphoid malignancies research[1].
References[1] Zhangchen, et al. Salt of compound for degrading btk, crystal form thereof, and use thereof in medicine. Patent WO2022052950A1.
1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)-(2563861-90-3) Related Product Information
PROTAC BTK Degrader-6 (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one Ibrutinib Impurity 10 1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- GBD-9 Ibrutinib