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| | (((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione Basic information |
| Product Name: | (((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione | | Synonyms: | (((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-[5-[[(2R)-1-ethyl-2-piperidinyl]methoxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;3-(5-(((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-{[(2R)-1-ethylpiperidin-2-yl]methoxy}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione;HbF inducer 2 | | CAS: | 2654011-51-3 | | MF: | C21H27N3O4 | | MW: | 385.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2654011-51-3.mol |  |
| | (((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Properties |
| Boiling point | 636.4±55.0 °C(predicted) | | density | 1.242±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 10.75±0.40(predicted) | | form | Solid | | color | White to off-white |
| | (((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione Usage And Synthesis |
| Uses | HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys[1]. | | References | [1] Ting PY, et al., A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science. 2024 Jul 5;385(6704):91-99. DOI:10.1126/science.adk6129 |
| | (((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione Preparation Products And Raw materials |
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