| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
| Email: |
han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:4-(4-Aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS:1957235-96-9
Purity:95% Package:250MG;1G Remarks:209687
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| | Pomalidomide-O-C4-NH2 Basic information |
| Product Name: | Pomalidomide-O-C4-NH2 | | Synonyms: | 1H-Isoindole-1,3(2H)-dione, 4-(4-aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-;Thalidomide-4-O-C4-NH2;4-(4-Aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;4-(4-aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | | CAS: | 1957235-96-9 | | MF: | C17H19N3O5 | | MW: | 345.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1957235-96-9.mol |  |
| | Pomalidomide-O-C4-NH2 Chemical Properties |
| Boiling point | 620.4±55.0 °C(Predicted) | | density | 1.387±0.06 g/cm3(Predicted) | | pka | 10.70±0.40(Predicted) |
| | Pomalidomide-O-C4-NH2 Usage And Synthesis |
| Uses | Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | References | [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | Pomalidomide-O-C4-NH2 Preparation Products And Raw materials |
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