E3 Ligase Ligand-Linker Conjugates 20

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Thalidomide-O-amido-C8-NH2；E3 Ligase Ligand-Linker Conjugates 20;Cereblon Ligand-Linker Conjugates 2
CAS:1950635-15-0
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
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Products Intro: Product Name:N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS:1950635-15-0
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
Company Name: Shanghai Chaolan Chemical Technology Center  
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Products Intro: CAS:1950635-15-0
Purity:98 Package:1G,5G,10G,50G,100G,500G
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
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Products Intro: Product Name:N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide, Thalidomide-O-amido-C8-NH2
CAS:1950635-15-0
Purity:98% 纯度 Package:1克;5克;100克
Company Name: Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd  
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Products Intro: Product Name:N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS:1950635-15-0
Purity:95% Package:25mg;100mg;500mg;1g;5g
E3 Ligase Ligand-Linker Conjugates 20 Basic information
Product Name:E3 Ligase Ligand-Linker Conjugates 20
Synonyms:E3 Ligase Ligand-Linker Conjugates 20;Cereblon Ligand-Linker Conjugates 2;Thalidomide-O-amido-C8-NH2;N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;Acetamide, N-(8-aminooctyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;N-(8-aminooctyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide;N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide?, Thalidomide-O-amido-C8-NH2;N-(8-Aminooctyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
CAS:1950635-15-0
MF:C23H30N4O6
MW:458.51
EINECS:
Product Categories:
Mol File:1950635-15-0.mol
E3 Ligase Ligand-Linker Conjugates 20 Structure
E3 Ligase Ligand-Linker Conjugates 20 Chemical Properties
Boiling point 762.8±60.0 °C(Predicted)
density 1.295±0.06 g/cm3(Predicted)
pka10.68±0.40(Predicted)
Safety Information
MSDS Information
E3 Ligase Ligand-Linker Conjugates 20 Usage And Synthesis
UsesThalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
IC 50Cereblon
References[1] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
E3 Ligase Ligand-Linker Conjugates 20 Preparation Products And Raw materials
Tag:E3 Ligase Ligand-Linker Conjugates 20(1950635-15-0) Related Product Information
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 Ligase Ligand-Linker Conjugates 22 Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Thalidomide-linker 14 N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate E3 Ligase Ligand-Linker Conjugates 24 (TFA)