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NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT

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NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT Suppliers list
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NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT Basic information
Product Name:NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT
Synonyms:NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT;LY315920 sodiuM salt;[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid monosodium salt;LY 315920 sodium;LY 315920Na;Varespladib sodium;VARESPLADIB SODIUM (LY315920 SODIUM SALT)
CAS:172733-42-5
MF:C21H21N2NaO5
MW:404.4
EINECS:
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Mol File:172733-42-5.mol
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT Structure
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT Chemical Properties
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT Usage And Synthesis
UsesTreatment of sepsis (sPLA2inhibitor).
in vivo

Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg[1].

Animal Model:Male Hartley guinea pigs (300-500 g)[1]
Dosage:3 mg/kg, 10 mg/kg, and 30 mg/kg
Administration:Intravenous injection (Pharmacokinetic study)
Result:Consistent inhibition of sPLA2 activity in BAL fluid was observed. Reduced the human sPLA2-induced generation of TXA2 on BAL cells from guinea pigs.
IC 50sPLA2: 9 nM (IC50)
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT Preparation Products And Raw materials
Raw materialsS-3013
Tag:NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT(172733-42-5) Related Product Information
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT VARESPLADIB Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-4-yl]oxy]- S-3013 N-(p-amylcinnamoyl) Anthranilic Acid MANUMYCIN A